Detail Information for IndEnz0002019005
IED ID IndEnz0002019005
Enzyme Type ID protease019005
Protein Name Deubiquitinase DESI2
EC 3.4.19.12
Desumoylating isopeptidase 2
DeSI-2
PPPDE peptidase domain-containing protein 1
Protein FAM152A
Gene Name DESI2 FAM152A PPPDE1 RCJMB04_23d23
Organism Gallus gallus (Chicken)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken)
Enzyme Sequence MANQLVILNVYDMYWMNEYTSSLGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFMEDDIEKIVEELGKEFKGNAYHLMHKNCNHFSSALSEILCGKEIPRWVNRLAYFSSCIPFLQSCLPKEWLTPAALQSSVSQELQDELEEAEDAAASASLASSASGSRTGRHTKL
Enzyme Length 193
Uniprot Accession Number Q5ZIV7
Absorption
Active Site ACT_SITE 29; /evidence="ECO:0000255|PROSITE-ProRule:PRU01205"; ACT_SITE 107; /evidence="ECO:0000250|UniProtKB:Q9BSY9, ECO:0000255|PROSITE-ProRule:PRU01205"
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000250|UniProtKB:Q9BSY9};
DNA Binding
EC Number 3.4.19.12
Enzyme Function FUNCTION: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000250|UniProtKB:Q9BSY9}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Compositional bias (1); Domain (1); Region (1)
Keywords Cytoplasm;Hydrolase;Protease;Reference proteome;Ubl conjugation pathway
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D291}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 21,409
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda