Detail Information for IndEnz0002019009
IED ID IndEnz0002019009
Enzyme Type ID protease019009
Protein Name Intracisternal A-particle Gag-related polyprotein
Cleaved into: Matrix protein; Phosphorylated protein; Capsid protein; Nucleocapsid protein; Protease
EC 3.4.23.-
Gene Name gag
Organism Hamster intracisternal a-particle H18 (IAP-H18)
Taxonomic Lineage Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae unclassified Retroviridae Intracisternal A-particles Hamster intracisternal a-particle H18 (IAP-H18)
Enzyme Sequence MGSSQSVVTALQTVLKQRDLKIAPRTLQNFMKEVDRVAPWYACSGSLTVASWNKLGKELDRKHAEGDLCLGTKAIWKLVKNCLEDEACHPAIIESQGTLEEVQDSMSETERSERMGARKRKDMSKKKGPPQEVKKGGEKEGSYHSPLNKSKKKKKPESSQYPAVELEALELDNSDSDTLDSSEEGGLEEEVARYEEKRYHPDRHRPLKTKMNVRPPPINPAGSRPSAPPPYELRLNTGTDSFLPLEERRKIQMAFPVFENAEGGRVHTPVDYNQIKELAESVRNYGVNANFTTLQVERLANFAMTPTDWQTTVKAVLPNMGQYMEWKALWYDAAQAQARVNATAGRSSGHLTKIVQGPQEPFSDFVARMTEAASRIFGDSEQAMPLIEQLVYEQATQECRAAIAPRKSKGLQDWLRVCRELGGPLTNAGLAAAILQTHRYRDLSNRKACFNCGRMGHLKKDCQAPERTRESKLCYRCGKGYHRASECGIMDSGADKSIISLHWWPKSWPTVVSSHSLQGLGYQSSPAISASALTWRDAEGKQGCFTPYVLPLPVNLWGRDVLQAMGMTLTNE
Enzyme Length 572
Uniprot Accession Number P04023
Absorption
Active Site ACT_SITE 491; /note=Protease; shared with dimeric partner; /evidence=ECO:0000255|PROSITE-ProRule:PRU00275
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.23.-
Enzyme Function FUNCTION: [Protease]: The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell. {ECO:0000255|PROSITE-ProRule:PRU00275}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (6); Compositional bias (3); Domain (1); Region (1); Site (4); Zinc finger (2)
Keywords Aspartyl protease;Hydrolase;Metal-binding;Protease;Repeat;Transposable element;Zinc;Zinc-finger
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 63,931
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda