Detail Information for IndEnz0002019015
IED ID IndEnz0002019015
Enzyme Type ID protease019015
Protein Name Dipeptidyl peptidase family member 6
EC 3.4.14.-
Gene Name dpf-6 F44B9.1
Organism Caenorhabditis elegans
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans
Enzyme Sequence MLFLPILILNLLIITHAIDIIPREVLFQDPKYSSVSLSPDAKQVGYVAPDENGIRNVFTRCSSCSYSRQVTFETEHPILNYVWTAIPDVILFTQDNHGDENTRIYKKNISATAIAADKTQRVVISEKPMVKAMILSNNLISETVLIGMNDENPALHNIYAFNCQTDELKLVLQNRRFSIFFFDNDLNVRLASEEGPDGEMIYYRPRSNEGARTTEQNTWVEYLRIQHDDKAITMPITFDKSNNFMYWIMGDGSDLGNLVVFPFEDPQQKEILYTAQRAQIGNVLIHPTDKTLLAVTEVYHKPELFVANETFMEDLQYLVNMKPSGSMNIVSMSIDMSTWLVTYSSSDEPYDIYLYRRWNKKAELFMSTRPELKKYTLNKQIGFDFRARDEMTIQAYLSLPPQAPLLKSSQVPDGDRPYANLGMIPAVPQKMIVLVHGGPKARDHYGFSPMNAWLTNRGYSVLQVNFRGSTGFGKRLTNAGNGEWGRKMHFDILDAVEFAVSKGIANRSEVAVMGGSYGGYETLVALTFTPQTFACGVDIVGPSNLISLVQAIPPYWLGFRKDLIKMVGADISDEEGRQSLQSRSPLFFADRVTKPIMIIQGANDPRVKQAESDQFVAALEKKHIPVTYLLYPDEGHGVRKPQNSMEQHGHIETFLQQCLGGETQPFQPGQYNSSAIIKKIGIEGAAIARQNLQIAQNQFAQQLPRGPVAPSIFYRPPVRAQRVMLAPNQNVMNRIFPVQG
Enzyme Length 740
Uniprot Accession Number P34422
Absorption
Active Site ACT_SITE 516; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 604; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 636; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.14.-
Enzyme Function FUNCTION: Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Alternative sequence (4); Chain (1); Disulfide bond (1); Glycosylation (4); Topological domain (2); Transmembrane (1)
Keywords Alternative splicing;Aminopeptidase;Cell membrane;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 15338614; 17850180; 21177967; 22560298; 23800452; 25487147;
Motif
Gene Encoded By
Mass 83,500
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda