Detail Information for IndEnz0002019016
IED ID IndEnz0002019016
Enzyme Type ID protease019016
Protein Name Deoxyuridine 5'-triphosphate nucleotidohydrolase
dUTPase
EC 3.6.1.23
dUTP pyrophosphatase
Gene Name DUT F16
Organism Vaccinia virus (strain L-IVP) (VACV)
Taxonomic Lineage Viruses Varidnaviria Bamfordvirae Nucleocytoviricota Pokkesviricetes Chitovirales Poxviridae Chordopoxvirinae Orthopoxvirus Vaccinia virus Vaccinia virus (strain L-IVP) (VACV)
Enzyme Sequence MFNMNINSPVRFVKETNRAKSPTRQSPGAAGYDLYSAYDYTIPPGERQLIKTDISMSMPKICYGRIAPRSGLSLKGIDIGGGVIDEDYRGNIGVILINNGKCTFNVNTGDRIAQLIYQRIYYPELEEVQSLDSTNRGDQGFGSTGLR
Enzyme Length 147
Uniprot Accession Number P68635
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23;
DNA Binding
EC Number 3.6.1.23
Enzyme Function FUNCTION: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1)
Keywords Hydrolase;Magnesium;Metal-binding;Nucleotide metabolism
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 16,264
Kinetics
Metal Binding
Rhea ID RHEA:10248
Cross Reference Brenda