IED ID | IndEnz0002019017 |
Enzyme Type ID | protease019017 |
Protein Name |
Dipeptidyl peptidase family member 2 EC 3.4.14.- |
Gene Name | dpf-2 C27C12.7 |
Organism | Caenorhabditis elegans |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
Enzyme Sequence | MENDNYDVEEQGCSVFNGKHGYFARSCCVVFILIICVIFVFSVIFTFMQNPINLNSDNGFNQTSGNTSSLEATTLKPKFSSLMTTTRRFTFEQLFSGKQFLVDYYDYIWLPDGSFVQMNDDFTIRKQMKKIPLGSSVAEPFFNNGEYVKALSSNMKYAYGSKKVNELWRHSAEYLYHIVKINNKTVSTEQWHVGPEENSLIQAFYWNPNASSNDFVYVHNYNLYYQKDPEKPDGAIQLTVGGSTFNRFGLANWLYEEEILEASSAVWWSPSGRYVSYLRFDDREVNRIFLPKYTDDDSYVEYFELPYPKAGVQNNTLVTQYIWDSENHKIVETAPPNELSAANGDYYVLTNKWITMPRNGSDLGEERLVTVWANRDQNHVYFSLCNEQDCVMALSFQFSIDNRQLWVSPKDVRGVFPTETGFLTVLPHKHDDGNIYNHVAHVELDGTGTGKITKWIGENFDVILVLGYSSKIDALTFSAYGDGVGEFSTYIVREAMYSNKKTTLQKVTDQFEDCKTLGSQSADPTGQRIVVQCEKPFDNTRLYLVDVVDTTKKIMLEGGTKAVIPFDVPNMKFGKLKLPSGIDGHYMMLTPANLLDGAKIPLLLDIYGGPDSKQVFQKTPTAHAIQIVSQYDIAYARIDVRGTGGRGWDVKEAVYRKLGDAEVVDTLDMIRAFINTFGFIDEDRIAVMGWSYGGFLTSKIAIKDQGELVKCAISIAPVTDFKYYDSAYTERYLGQPAENLQGYINTNVIPHARNVTNVKYLLAHGERDDNVHYQNSARWSEALQQNGIHFTQLVYANEAHSLSHKLFHLYGEVQRFLMNDCFKSNLDLL |
Enzyme Length | 829 |
Uniprot Accession Number | Q18253 |
Absorption | |
Active Site | ACT_SITE 691; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 768; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 800; /note=Charge relay system; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.14.- |
Enzyme Function | FUNCTION: Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration. {ECO:0000250, ECO:0000269|Ref.3}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (3); Chain (1); Disulfide bond (2); Glycosylation (7); Topological domain (2); Transmembrane (1) |
Keywords | Aminopeptidase;Cell membrane;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 10778742; 15338614; 17164286; 17850180; 19343510; 21177967; 22267497; 22347378; 22560298; 23800452; 24884423; 25487147; 6593563; |
Motif | |
Gene Encoded By | |
Mass | 94,387 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |