| IED ID | IndEnz0002019028 |
| Enzyme Type ID | protease019028 |
| Protein Name |
Dipeptidyl-peptidase 4 EC 3.4.14.- Dipeptidyl-aminopeptidase Dipeptidylpeptidase IV DPP IV |
| Gene Name | DPP |
| Organism | Giardia intestinalis (Giardia lamblia) |
| Taxonomic Lineage | cellular organisms Eukaryota Metamonada Fornicata Diplomonadida Hexamitidae Giardiinae Giardia Giardia intestinalis (Giardia lamblia) |
| Enzyme Sequence | MTLSAWIILVTLAMASVLTPEDNVRLRRLTAYVANADASIVLLTYTEYEEGTNHGNSMLWRINDPLEAEYPFDPDDISLLNAERVCPELVGVGDLQYSTHNQAFYFTAQGPDGTSQVYSYNHKLETCTQISFLPISVSNLKVSPKGNSVLFSAEIFVYPNNHASVDDPLNFAHDEFARIQARPYKAFAYEQLYTRHWDEDILPSQYRHLFAARLERSSEYDDDYVRITVDNSIDLMPRFDGDCPMRPFADASSYTFDSHGRYVAFVTQVGSTAAFYTNDSIWITDLQQFLDAKKPVRDVVLPLRCATCWNKARDQRPAFSYDGIFLYYASMDEEQSESDLLRLRKQNVSDLFEYDCDSLFCGPVTGEGVFNLTAGVFDRSIGQFIIPTDSTEDSIYILAEDHARTNLFRYNEESSTVTRLTYNGTLGSLLYLRHNKIFLATMSSYTRPTDLVMLDLTVATEFTATRDPSDTMKDDLIKISYLTDLNRQRLRHIDELQEPEEFYLPSKSFPDQYVHSWYFAPANLRDSHEYPLILYVHGGPESPWANSWSYRWNPQLIAARGYGVLATNFHGSSSFGEVFQKSVRGNWYSYPLEDIMDAWSNIYTHADKAYLSREKVCAMGASFGATFMNYMNSHVNNVTCYVTHDGVFDTMCNALETDELFFPVRELGGFLLDEQVDNQQLYEKWNPARFVENMSAPMLVIHGQKDYRIQVYHGISLFQALRLRGIKTKLVYFPTQSHWVWQPQESLFWHTQVFDWLDTYL |
| Enzyme Length | 761 |
| Uniprot Accession Number | Q95WU5 |
| Absorption | |
| Active Site | ACT_SITE 622; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 706; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 738; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.14.- |
| Enzyme Function | FUNCTION: May be involved in metabolism of dipeptides or may affect host defense mechanisms. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Signal peptide (1) |
| Keywords | Aminopeptidase;Direct protein sequencing;Hydrolase;Membrane;Protease;Signal |
| Interact With | |
| Induction | INDUCTION: Expression increased in response to the protease inhibitor bestatin. {ECO:0000269|PubMed:12049634}. |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:12049634}. Note=Associated with trophozoite membrane. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..15; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 87,648 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |