IED ID | IndEnz0002019028 |
Enzyme Type ID | protease019028 |
Protein Name |
Dipeptidyl-peptidase 4 EC 3.4.14.- Dipeptidyl-aminopeptidase Dipeptidylpeptidase IV DPP IV |
Gene Name | DPP |
Organism | Giardia intestinalis (Giardia lamblia) |
Taxonomic Lineage | cellular organisms Eukaryota Metamonada Fornicata Diplomonadida Hexamitidae Giardiinae Giardia Giardia intestinalis (Giardia lamblia) |
Enzyme Sequence | MTLSAWIILVTLAMASVLTPEDNVRLRRLTAYVANADASIVLLTYTEYEEGTNHGNSMLWRINDPLEAEYPFDPDDISLLNAERVCPELVGVGDLQYSTHNQAFYFTAQGPDGTSQVYSYNHKLETCTQISFLPISVSNLKVSPKGNSVLFSAEIFVYPNNHASVDDPLNFAHDEFARIQARPYKAFAYEQLYTRHWDEDILPSQYRHLFAARLERSSEYDDDYVRITVDNSIDLMPRFDGDCPMRPFADASSYTFDSHGRYVAFVTQVGSTAAFYTNDSIWITDLQQFLDAKKPVRDVVLPLRCATCWNKARDQRPAFSYDGIFLYYASMDEEQSESDLLRLRKQNVSDLFEYDCDSLFCGPVTGEGVFNLTAGVFDRSIGQFIIPTDSTEDSIYILAEDHARTNLFRYNEESSTVTRLTYNGTLGSLLYLRHNKIFLATMSSYTRPTDLVMLDLTVATEFTATRDPSDTMKDDLIKISYLTDLNRQRLRHIDELQEPEEFYLPSKSFPDQYVHSWYFAPANLRDSHEYPLILYVHGGPESPWANSWSYRWNPQLIAARGYGVLATNFHGSSSFGEVFQKSVRGNWYSYPLEDIMDAWSNIYTHADKAYLSREKVCAMGASFGATFMNYMNSHVNNVTCYVTHDGVFDTMCNALETDELFFPVRELGGFLLDEQVDNQQLYEKWNPARFVENMSAPMLVIHGQKDYRIQVYHGISLFQALRLRGIKTKLVYFPTQSHWVWQPQESLFWHTQVFDWLDTYL |
Enzyme Length | 761 |
Uniprot Accession Number | Q95WU5 |
Absorption | |
Active Site | ACT_SITE 622; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 706; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 738; /note=Charge relay system; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.14.- |
Enzyme Function | FUNCTION: May be involved in metabolism of dipeptides or may affect host defense mechanisms. {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (3); Chain (1); Signal peptide (1) |
Keywords | Aminopeptidase;Direct protein sequencing;Hydrolase;Membrane;Protease;Signal |
Interact With | |
Induction | INDUCTION: Expression increased in response to the protease inhibitor bestatin. {ECO:0000269|PubMed:12049634}. |
Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:12049634}. Note=Associated with trophozoite membrane. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..15; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 87,648 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |