Detail Information for IndEnz0002019036
IED ID IndEnz0002019036
Enzyme Type ID protease019036
Protein Name Alpha-1-antiproteinase S
APS
Alpha-1-antitrypsin
Alpha-1-proteinase inhibitor
Gene Name
Organism Cavia porcellus (Guinea pig)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Hystricomorpha Caviidae (cavies) Cavia (guinea pigs) Cavia porcellus (Guinea pig)
Enzyme Sequence MPSAIPRGLLLLAGLCCLVFGIMAEDAQVAQGPSQQIPRSLAHFAHSMYRVLTQQSNTSNIFFSPVSIATALAMVSVGAKGDTHTQILRGLEFNLTEIAEADIHNGFQNLLHTLNRPHSEHQLTTGNGLFLDQKLKLKEKFSEDVKTLYHAEAFPTNFSNPKEAEKQINAYVEKGTQGKIVDLVKDLSADTVLALVNYIFFRGKWEKPFDVKHTTQEDFHVDTSTTVKVPMMKREGKYKAFHCSTIQSWVLLLDYEGNVTALFLLPEEGKMQHLEETLTPELIFKFARKTERMFANVHLPKLSISGTYDLKEVLGHLGITNVFSDAADLSGVTEDIPLKISKGLHKALLTIDEKGTEAAGATMMEFMPMSLPEDLSFNKPFLFLIIDHSTDTPLFVGKVMDPTKK
Enzyme Length 405
Uniprot Accession Number P22325
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Inhibits elastase, chymotrypsin, cathepsin G, plasmin, and trypsin.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Glycosylation (4); Region (1); Signal peptide (1); Site (1)
Keywords Acute phase;Direct protein sequencing;Glycoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal
Interact With
Induction INDUCTION: APS rose several hundred-fold during the acute phase reaction.
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..24; /evidence=ECO:0000269|PubMed:1985973
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 45,125
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda