Detail Information for IndEnz0002019075
IED ID IndEnz0002019075
Enzyme Type ID protease019075
Protein Name Dipeptidyl peptidase 1
EC 3.4.14.1
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
DPP-I
DPPI
Dipeptidyl transferase

Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain
Dipeptidyl peptidase I exclusion domain chain
; Dipeptidyl peptidase 1 heavy chain
Dipeptidyl peptidase I heavy chain
; Dipeptidyl peptidase 1 light chain
Dipeptidyl peptidase I light chain
Gene Name CTSC
Organism Bos taurus (Bovine)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine)
Enzyme Sequence MGPWSGSRLVALLLLVYGAGSVRGDTPANCTYPDLLGTWVFQVGSSGSQRDVNCSVMGPPEKKVVVHLKKLDTAYDDFGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGGKVTSYCHETMTGWVHDVLGRNRACFTGRKTGNTSENVNVNTARLAGLEETYSNRLYRYNHDFVKAINAIQKSWTAAPYMEYETLTLKEMIRRGGGHSRRIPRPKPAPITAEIQKKILHLPTSWDWRNVHGINFVTPVRNQGSCGSCYSFASMGMMEARIRILTNNTQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEDCFPYTGTDSPCRLKEGCFRYYSSEYHYVGGFYGGCNEALMKLELVHQGPMAVAFEVYDDFLHYRKGVYHHTGLRDPFNPFELTNHAVLLVGYGTDAASGLDYWIVKNSWGTSWGENGYFRIRRGTDECAIESIALAATPIPKL
Enzyme Length 463
Uniprot Accession Number Q3ZCJ8
Absorption
Active Site ACT_SITE 258; /evidence=ECO:0000250; ACT_SITE 405; /evidence=ECO:0000250; ACT_SITE 427; /evidence=ECO:0000250
Activity Regulation
Binding Site BINDING 302; /note=Chloride; /evidence=ECO:0000250; BINDING 304; /note=Chloride; via amide nitrogen; /evidence=ECO:0000250; BINDING 347; /note=Chloride; /evidence=ECO:0000250
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.; EC=3.4.14.1;
DNA Binding
EC Number 3.4.14.1
Enzyme Function FUNCTION: Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Binding site (3); Chain (3); Disulfide bond (5); Glycosylation (4); Propeptide (1); Signal peptide (1)
Keywords Chloride;Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Signal;Thiol protease;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..24; /evidence=ECO:0000250
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 51,949
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.4.14.1;