Detail Information for IndEnz0002019093
IED ID IndEnz0002019093
Enzyme Type ID protease019093
Protein Name Carboxypeptidase Y homolog A
EC 3.4.16.5
Carboxypeptidase 3
Gene Name cpyA AFUA_6G13540
Organism Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Enzyme Sequence MRVLPATLLVGAATAAAPPFQQILGLPKKSADTLAKPLHDLQEQLKTLSGEARHLWDEVASHFPNNMDHNPVFSLPKKHTRRPDSHWDHIVRGADVQSVWVAGASGEKEREIDGKLEAYDLRVKKTDPSALGIDPGVKQYTGYLDDNENDKHLFYWFFESRNDPKNDPVVLWLNGGPGCSSLTGLFLELGPSSINEKIKPIYNDFAWNSNASVIFLDQPVNVGYSYSGAAVSDTVAAGKDVYALLTLFFKQFPEYAKQDFHIAGESYAGHYIPVFASEILSHKKRNINLKSVLIGNGLTDGLTQYDYYRPMACGEGGYPAVLDESSCQSMDNALPRCKSMIESCYNTESSWICVPASIYCNNALLGPYQRTGQNVYDIRGKCEDSSNLCYKGMGYVSEYLNKREVREAVGAEVDGYESCNFDINRNFLFHGDWMKPYHRLVPGLLEQIPVLIYAGDADFICNWLGNKAWTEALEWPGQKEYAPLPLKDLVIEENEHKGKKIGQIKSHGNFTFMRLYGAGHMVPMDQPEASLEFFNRWLGGEWF
Enzyme Length 543
Uniprot Accession Number Q5VJG9
Absorption
Active Site ACT_SITE 266; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 458; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 520; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of a C-terminal amino acid with broad specificity.; EC=3.4.16.5; Evidence={ECO:0000255|PROSITE-ProRule:PRU10074};
DNA Binding
EC Number 3.4.16.5
Enzyme Function FUNCTION: Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (5); Glycosylation (2); Propeptide (1); Signal peptide (1)
Keywords Carboxypeptidase;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Signal;Vacuole;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..17; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 60,917
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda