| IED ID | IndEnz0002019094 |
| Enzyme Type ID | protease019094 |
| Protein Name |
Cathepsin L2 EC 3.4.22.43 Cathepsin U Cathepsin V |
| Gene Name | CTSV CATL2 CTSL2 CTSU UNQ268/PRO305 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV |
| Enzyme Length | 334 |
| Uniprot Accession Number | O60911 |
| Absorption | |
| Active Site | ACT_SITE 138; /evidence=ECO:0000269|PubMed:11027133; ACT_SITE 277; /evidence=ECO:0000269|PubMed:11027133; ACT_SITE 301; /evidence=ECO:0000269|PubMed:11027133 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by CST6. {ECO:0000269|PubMed:30425301}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).; EC=3.4.22.43; Evidence={ECO:0000269|PubMed:10029531}; |
| DNA Binding | |
| EC Number | 3.4.22.43 |
| Enzyme Function | FUNCTION: Cysteine protease. May have an important role in corneal physiology. {ECO:0000269|PubMed:10029531, ECO:0000269|PubMed:9727401}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (11); Chain (1); Disulfide bond (3); Glycosylation (2); Helix (10); Propeptide (1); Sequence conflict (1); Signal peptide (1); Turn (2) |
| Keywords | 3D-structure;Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Lysosome {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (3) |
| Cross Reference PDB | 1FH0; 3H6S; 3KFQ; |
| Mapped Pubmed ID | 10072072; 10229672; 10631941; 10748235; 10809954; 10966814; 11684289; 11813165; 11853874; 12078484; 12504904; 12648222; 12742663; 12748383; 12809493; 12925692; 15192101; 15308097; 15679121; 16181339; 16565075; 17516850; 17869649; 17889653; 18163891; 18572095; 19846555; 20347002; 20536394; 21604257; 21784848; 22393040; 22452389; 22562303; 23090970; 23287360; 23542171; 23871919; 24121514; 24412244; 26638075; 27771373; 28522343; 29623762; 29654760; 30759440; 31444238; 32007579; 32910988; 32912629; 32918681; 7896811; 8576151; 8687433; 9008168; 9539769; 9545226; |
| Motif | |
| Gene Encoded By | |
| Mass | 37,329 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.43; |