Detail Information for IndEnz0002019096
IED ID IndEnz0002019096
Enzyme Type ID protease019096
Protein Name Cathepsin L 2
EC 3.4.22.15
Gene Name GSPATT00022898001
Organism Paramecium tetraurelia
Taxonomic Lineage cellular organisms Eukaryota Sar Alveolata Ciliophora Intramacronucleata Oligohymenophorea Peniculida Parameciidae Paramecium Paramecium tetraurelia
Enzyme Sequence MMLLGASLYLNNTQEVSDEIDTANLYANWKMKYNRRYTSQRDEMYRFKVFSDNLNYIRAFQDSTESATYTLELNQFADMSQQEFASTYLSLRVPKTAKLNASNANFQYKGAEVDWTDNKKVKYPAVKNQGSCGSCWAFSAVGALEINTDIELNKKYELSEQDLVDCSGPYDNEGCNGGWMDSAFEYVADNGLAEAKDYPYTAKDGTCKTSVKRPYTHVQGFTDIDSCDELAQAIQERTVSVAVDANPWQFYRSGVLSKCTKNLNHGVVLVGVQADGAWKIRNSWGSSWGEAGHIRLAGGDTCGICAAPSFPILG
Enzyme Length 314
Uniprot Accession Number A0E358
Absorption
Active Site ACT_SITE 135; /evidence=ECO:0000255|PROSITE-ProRule:PRU10088; ACT_SITE 265; /evidence=ECO:0000255|PROSITE-ProRule:PRU10088; ACT_SITE 282; /evidence=ECO:0000255|PROSITE-ProRule:PRU10088
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.; EC=3.4.22.15;
DNA Binding
EC Number 3.4.22.15
Enzyme Function FUNCTION: May be involved in extracellular digestion. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (3); Erroneous initiation (1); Propeptide (1); Signal peptide (1)
Keywords Disulfide bond;Hydrolase;Protease;Reference proteome;Secreted;Signal;Thiol protease;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..24; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 34,935
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda