IED ID | IndEnz0002019101 |
Enzyme Type ID | protease019101 |
Protein Name |
Disintegrin and metalloproteinase domain-containing protein 33 ADAM 33 EC 3.4.24.- |
Gene Name | Adam33 |
Organism | Mus musculus (Mouse) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
Enzyme Sequence | MGSRCGRPGGSPVLLLLPLLLPSCPLRSARMFPGNAHGELVTPHWILEGRLWLKVTLEEPILKPDSVLVALEAEGQDLLLELEKKHKLLAPGYTETHYRPDGHPVVLSPNHTDHCQYHGRVRGFRESWVVLSTCSGMSGLIVLSSKVSYYLQPRTPGDTKDFPTHEIFRMEQLFTWRGVQRDKNSQYKAGMASLPHVPQSRVRREARRSPRYLELYIVADHTLFLLQHQNLNHTRQRLLEVANCVDQILRTLDIQLVLTGLEVWTEQDLSRITQDANETLWAFLQWRRGVWARRPHDSTQLLTGRTFQGTTVGLAPVEGICRAESSGGVSTDHSELPIGTAATMAHEIGHSLGLHHDPEGCCVQADAEQGGCVMEAATGHPFPRVFSACSRRQLRTFFRKGGGPCLSNTSAPGLLVLPSRCGNGFLEAGEECDCGSGQKCPDPCCFAHNCSLRAGAQCAHGDCCARCLLKSAGTPCRPAATDCDLPEFCTGTSPYCPADVYLLDGSPCAEGRGYCLDGWCPTLEQQCQQLWGPGSKPAPEPCFQQMNSMGNSQGNCGQDHKGSFLPCAQRDALCGKLLCQGGEPNPLVPHIVTMDSTILLEGREVVCRGAFVLPDSHLDQLDLGLVEPGTGCGPRMVCQDRHCQNATSQELERCLTACHNGGVCNSNRNCHCAAGWAPPFCDKPGLGGSVDSGPAQSANRDAFPLAMLLSFLLPLLPGAGLAWCYYQLPTFCHRRGLCCRRDPLWNRDIPLGSVHPVEFGSIITGEPSPPPPWTSCQQRSHPPSLDLLSDPANSELT |
Enzyme Length | 797 |
Uniprot Accession Number | Q923W9 |
Absorption | |
Active Site | ACT_SITE 347; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.24.- |
Enzyme Function | |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (1); Alternative sequence (1); Chain (1); Disulfide bond (7); Domain (3); Glycosylation (6); Metal binding (4); Motif (1); Propeptide (1); Region (1); Sequence conflict (4); Signal peptide (1); Topological domain (2); Transmembrane (1) |
Keywords | Alternative splicing;Cleavage on pair of basic residues;Direct protein sequencing;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zinc;Zymogen |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
Modified Residue | |
Post Translational Modification | PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}. |
Signal Peptide | SIGNAL 1..29; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 10086356; 11897009; 12110844; 12466851; 12972401; 15063736; 15657107; 16079176; 16141072; 16943435; 19665773; 20562862; 21677750; |
Motif | MOTIF 132..139; /note=Cysteine switch; /evidence=ECO:0000250 |
Gene Encoded By | |
Mass | 86,971 |
Kinetics | |
Metal Binding | METAL 134; /note=Zinc; in inhibited form; /evidence=ECO:0000250; METAL 346; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:Q9BZ11; METAL 350; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:Q9BZ11; METAL 356; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:Q9BZ11 |
Rhea ID | |
Cross Reference Brenda |