| IED ID | IndEnz0002019129 |
| Enzyme Type ID | protease019129 |
| Protein Name |
Putative aminopeptidase-2 EC 3.4.11.- |
| Gene Name | T16G12.1 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MRRKLLLLLCFIGLFSLISTAPAPNNVGLESEFTEGHAETINLEEVEFNHPSILPEHPDNFRQDKLAARKRQSLYVTKTRLPPNLYAIDYSLWFQPYFPSPGVQYAPEKNFTFDGRASIQVEALVASDRFILNAYNFKIQSYKVVDIDGTVVPINSISQDDTTQQLSLITNANGVVAGQIYNIEFVYTGIINPYTDGGVYYTSYNDPQGNTHYMIATHMEPFSARKVFPSLDEPSYKAKFTITVQYPASQVALSNMMETEPTKIDNIWSTITFPQTPKMSSYLIAFAVGPYVNSQYVNKHNTLTRAWGWPGTEQYLQFAAQNAGECLYQLGEYTGIKFPLSKADQLGMPEFLAGAMENWGLIIYKYQYIAYNPTTMTTRNMEAAAKVMCHELAHQWFGDLVTTAWWDDLFLNEGFADYFMTFIQKSVYPQQATYLDTLQVLDELQVGLTADVRYDAHPLVYPDGPAFDDITYNKGASMLRMLSDVLGADVFKQGIRAYLQKMQYSNANDFDLFSTLTDTAKSNNILDWCGLPLNVTDFMQPYIHQTNHPLIRYNNNQKIGGSTFSQEPFLDISDLTATPWNYTWSIPLTSANLRHADPYKQWLPRQQGCANMNENIQEERIKEPNKRAVQWELTSITSATYGRIIYDDIGFDRILKLIKQDDINDNLKLTLLADEYNYMLREKKANRPFGYNRFLDLAKVIFNTQSFTNYPSYGVFAQAQPVLEQIAQLYRDGIDAEFVPRLYKLFFQNSYNQLKWQDTSIWDTDTFSEVFLPFAVRYDIGDVQNRTLNMFANVKSACINSLNGTAWCNPYSTNLRKAIYCGAAKYAPATSDYFFQMLHSYNKEVITNPYFYQEYMALLEGMSCTQSPATLKVLIRLFTTSTLNPSTIFGFLKYNPAASDVLYNYFMANPQLVNSTMLDAYLDAMTYNWNSYFREGQLSTLMNTLTLTNDQFDIFDFYINRVSLMFEYKSTYALPTYNWLYDNLVVIGKTPWEKTPNIDAVFPYYKLDLQVNIPGSGPYQWYENMTFSATSTVTFQLVSPTSSITINAHRLMFDPVSIRLYNENDENAHTPIPIDFSKVMKDYDKGTVTIPTMNNTVLYPNQYSLFIEYTGFIFQNPDEGDASNTYLGGLNNRKGWIFTTDFEGGPGARSLLPCWDEPSYKGQFEVSVFHPTDMIALSNEVDIQRTIYDNGWTTTKFATTNQMSTYLLALCVGHFSNLATVTRTGVLTRVWTWSGMEQYGEFALNVTAGTIDFMENYFSYDFPLKKLDVMALPEYTMNAGAMENWGLIIGEYSLFMFDPDYATTRDITEVAETTAHEVVHQWFGDIVTLDWWNDIFLNEGFAQYWFANGIDNTFPEQHAYSIDYNRFYMNHIALKYDCIPGVAKPVISDTPPVFGIEPYYKGSALLNLLNNVLTPAVFQEGLSSYLTQYGYVNASPRNLWTSLTVAAQRHNITDWNGQPLDVSSFMDPYTLQTSYPIITLTLRGTSTVQANQQSCMSDETLWNVPLFTQTPGALDFNWFVNFTGGNDATWLRPLPTGYRVDNAGSTSFARINYDDKSWYSIQAQLLSNMNTMSSTTRAMLLDDANFFYQSGRWEMTKFLDLTLYLVNEDSLAPWEQAIEFFTEMLNRFQYQPEIDTVRNYVIQITKNAVSKFQWNTNGLWANDRIVQLLVNVNNLAVNRQSRQVALTLFNNFVLKCKYSLSGTGKCSGIHPNLRQPTYCYGLRQSNNIDDFTTVNNLYSWFVQNAGYLQTDGSNLLNALGCVQNLDLQKTMLRSILSGDYPPSLLNSIAVHDDSSDVLYNFLLDNTQDILNAPFDFSLYVKAMFQNWSTSNQLELAKDFQNSSNYNLLNAAQKNIYKQGILTVNSNANWMLIYKTPFLEWIQKNFGAPNL |
| Enzyme Length | 1890 |
| Uniprot Accession Number | Q22531 |
| Absorption | |
| Active Site | ACT_SITE 391; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; ACT_SITE 1317; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | BINDING 220; /note=Substrate; /evidence=ECO:0000250|UniProtKB:Q6P179; BINDING 1143; /note=Substrate; /evidence=ECO:0000250|UniProtKB:Q6P179 |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.11.- |
| Enzyme Function | FUNCTION: Putative aminopeptidase which plays a role in oocyte maturation. {ECO:0000269|PubMed:24663498}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Binding site (2); Chain (1); Glycosylation (13); Metal binding (6); Region (2); Signal peptide (1) |
| Keywords | Aminopeptidase;Differentiation;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Oogenesis;Protease;Reference proteome;Signal;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 15791247; 17164286; 19343510; 20439774; 21085631; 21177967; 21367940; 22267497; 22286215; 22347378; 22560298; 23800452; 24884423; 25487147; 29348603; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 216,241 |
| Kinetics | |
| Metal Binding | METAL 390; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 394; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 413; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:Q6P179; METAL 1316; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 1320; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 1339; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:Q6P179 |
| Rhea ID | |
| Cross Reference Brenda |