Detail Information for IndEnz0002019238
IED ID IndEnz0002019238
Enzyme Type ID protease019238
Protein Name Cysteine proteinase 3
EC 3.4.22.-
Cysteine proteinase ACP3
Fragment
Gene Name CPNP
Organism Entamoeba histolytica
Taxonomic Lineage cellular organisms Eukaryota Amoebozoa Evosea Archamoebae Mastigamoebida Entamoebidae Entamoeba Entamoeba histolytica
Enzyme Sequence LAIANAIDFNTWAANNNKHFTAVEALRRRAIFNMNARFVAEFNKKGSFKLSVDGPFAAMTNEEYRTLLKSKRTVEENGKVTYLNIQAPESVDWRAQGKVTPIRDQAQCGSCYTFGSLAALEGRLLIEKGGNANTLDLSEEHLVQCTRDNGNNGCNGGLGSNVYDYIIQNGVAKESDYPYTGTDSTCKTNVKAFAKITGYNKVPRNNEAELKAALSQGLVDVSIDASSAKFQLYKSGAYSDTKCKNNFFALNHEVCAVGYGVVDGKECWIVRNSWGTGWGDKGYINMVIEGNTCGVATDPLYPTGVQYL
Enzyme Length 308
Uniprot Accession Number Q06964
Absorption
Active Site ACT_SITE 111; /evidence=ECO:0000250; ACT_SITE 252; /evidence=ECO:0000250; ACT_SITE 272; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.22.-
Enzyme Function FUNCTION: Can abolish adhesion and degrade matrix proteins such as collagen, laminin and fibronectin.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (2); Non-terminal residue (1); Propeptide (1); Signal peptide (1)
Keywords Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Secreted;Signal;Thiol protease;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL <1..?; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 33,680
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda