| IED ID |
IndEnz0002019242 |
| Enzyme Type ID |
protease019242 |
| Protein Name |
Ecotin
|
| Gene Name |
eco eti b2209 JW2197 |
| Organism |
Escherichia coli (strain K12) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Proteobacteria
Gammaproteobacteria
Enterobacterales
Enterobacteriaceae
Escherichia
Escherichia coli
Escherichia coli (strain K12)
|
| Enzyme Sequence |
MKTILPAVLFAAFATTSAWAAESVQPLEKIAPYPQAEKGMKRQVIQLTPQEDESTLKVELLIGQTLEVDCNLHRLGGKLENKTLEGWGYDYYVFDKVSSPVSTMMACPDGKKEKKFVTAYLGDAGMLRYNSKLPIVVYTPDNVDVKYRVWKAEEKIDNAVVR |
| Enzyme Length |
162 |
| Uniprot Accession Number |
P23827 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (13); Chain (1); Disulfide bond (1); Erroneous initiation (1); Helix (3); Signal peptide (1); Site (1); Turn (1) |
| Keywords |
3D-structure;Direct protein sequencing;Disulfide bond;Periplasm;Protease inhibitor;Reference proteome;Serine protease inhibitor;Signal |
| Interact With |
P03951; P00763 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Periplasm. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..20; /evidence="ECO:0000269|PubMed:2007606, ECO:0000269|PubMed:9298646" |
| Structure 3D |
X-ray crystallography (20) |
| Cross Reference PDB |
1AZZ;
1ECY;
1ECZ;
1EZS;
1EZU;
1FI8;
1ID5;
1IFG;
1N8O;
1P0S;
1SLU;
1SLV;
1SLW;
1SLX;
1XX9;
1XXD;
1XXF;
4IW4;
4NIY;
7CBK;
|
| Mapped Pubmed ID |
10966645;
10966646;
11352586;
12834348;
14579355;
1537814;
15545266;
16606699;
23861840;
24520050;
32657577;
8508953;
8634241;
9518472;
9521759;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
18,192 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|