IED ID |
IndEnz0002019242 |
Enzyme Type ID |
protease019242 |
Protein Name |
Ecotin
|
Gene Name |
eco eti b2209 JW2197 |
Organism |
Escherichia coli (strain K12) |
Taxonomic Lineage |
cellular organisms
Bacteria
Proteobacteria
Gammaproteobacteria
Enterobacterales
Enterobacteriaceae
Escherichia
Escherichia coli
Escherichia coli (strain K12)
|
Enzyme Sequence |
MKTILPAVLFAAFATTSAWAAESVQPLEKIAPYPQAEKGMKRQVIQLTPQEDESTLKVELLIGQTLEVDCNLHRLGGKLENKTLEGWGYDYYVFDKVSSPVSTMMACPDGKKEKKFVTAYLGDAGMLRYNSKLPIVVYTPDNVDVKYRVWKAEEKIDNAVVR |
Enzyme Length |
162 |
Uniprot Accession Number |
P23827 |
Absorption |
|
Active Site |
|
Activity Regulation |
|
Binding Site |
|
Calcium Binding |
|
catalytic Activity |
|
DNA Binding |
|
EC Number |
|
Enzyme Function |
FUNCTION: General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity. |
Temperature Dependency |
|
PH Dependency |
|
Pathway |
|
nucleotide Binding |
|
Features |
Beta strand (13); Chain (1); Disulfide bond (1); Erroneous initiation (1); Helix (3); Signal peptide (1); Site (1); Turn (1) |
Keywords |
3D-structure;Direct protein sequencing;Disulfide bond;Periplasm;Protease inhibitor;Reference proteome;Serine protease inhibitor;Signal |
Interact With |
P03951; P00763 |
Induction |
|
Subcellular Location |
SUBCELLULAR LOCATION: Periplasm. |
Modified Residue |
|
Post Translational Modification |
|
Signal Peptide |
SIGNAL 1..20; /evidence="ECO:0000269|PubMed:2007606, ECO:0000269|PubMed:9298646" |
Structure 3D |
X-ray crystallography (20) |
Cross Reference PDB |
1AZZ;
1ECY;
1ECZ;
1EZS;
1EZU;
1FI8;
1ID5;
1IFG;
1N8O;
1P0S;
1SLU;
1SLV;
1SLW;
1SLX;
1XX9;
1XXD;
1XXF;
4IW4;
4NIY;
7CBK;
|
Mapped Pubmed ID |
10966645;
10966646;
11352586;
12834348;
14579355;
1537814;
15545266;
16606699;
23861840;
24520050;
32657577;
8508953;
8634241;
9518472;
9521759;
|
Motif |
|
Gene Encoded By |
|
Mass |
18,192 |
Kinetics |
|
Metal Binding |
|
Rhea ID |
|
Cross Reference Brenda |
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