Detail Information for IndEnz0002019290
IED ID IndEnz0002019290
Enzyme Type ID protease019290
Protein Name Cold shock-like protein CspD
CSP-D
Gene Name cspD cspH ybjA b0880 JW0864
Organism Escherichia coli (strain K12)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia Escherichia coli Escherichia coli (strain K12)
Enzyme Sequence MEKGTVKWFNNAKGFGFICPEGGGEDIFAHYSTIQMDGYRTLKAGQSVQFDVHQGPKGNHASVIVPVEVEAAVA
Enzyme Length 74
Uniprot Accession Number P0A968
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells.; FUNCTION: Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR. Overproduction is toxic.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Domain (1); Sequence conflict (1)
Keywords Cytoplasm;DNA replication inhibitor;DNA-binding;Direct protein sequencing;RNA-binding;Reference proteome;Toxin
Interact With P0AAG0
Induction INDUCTION: Not induced by cold-shock. Stationary-phase and starvation inducible, as well as by oxidative stress (30 mM H(2)O(2)). Repressed by MqsA and MqsRA toxin-antitoxin system. {ECO:0000269|PubMed:20105222}.
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 15690043; 16606699; 24561554;
Motif
Gene Encoded By
Mass 7,969
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda