| IED ID | IndEnz0002019305 |
| Enzyme Type ID | protease019305 |
| Protein Name |
COP9 signalosome complex subunit 6 SGN6 Signalosome subunit 6 JAB1-containing signalosome subunit 6 MOV34 homolog Vpr-interacting protein hVIP |
| Gene Name | COPS6 CSN6 HVIP |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF |
| Enzyme Length | 327 |
| Uniprot Accession Number | Q7L5N1 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:9535219}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (9); Chain (1); Domain (1); Erroneous initiation (1); Helix (5); Region (1); Turn (1) |
| Keywords | 3D-structure;Cytoplasm;Direct protein sequencing;Host-virus interaction;Nucleus;Reference proteome;Signalosome |
| Interact With | Q13515; Q9BX70; Q9Y297; Q6UXH8-3; Q8NHY2; Q9UNS2; Q9BT78; Q92905; P28482; P31947; Q92529; Q8N6Y0; Q15911-2 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9535219}. Cytoplasm {ECO:0000269|PubMed:9535219}.; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:9520381}. Note=(Microbial infection) The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. {ECO:0000269|PubMed:9520381}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | Electron microscopy (4); X-ray crystallography (5) |
| Cross Reference PDB | 4D10; 4D18; 4QFT; 4R14; 4WSN; 6R6H; 6R7F; 6R7H; 6R7I; |
| Mapped Pubmed ID | 10391953; 12944386; 14667819; 14742321; 15383276; 15757663; 15811629; 15882621; 16169070; 16223728; 16401342; 16916636; 16943200; 17183367; 17337451; 17353931; 17882165; 18060501; 18093314; 18926707; 19109893; 19214193; 19367725; 19549727; 19609301; 19615732; 19748355; 20360068; 20467437; 20711500; 20855601; 21102408; 21135142; 21317535; 21388382; 21555518; 21900206; 21903422; 21988832; 22118460; 22190034; 22959436; 23095642; 23187808; 23414517; 23453757; 23535662; 23535663; 23583660; 24421388; 25043011; 25144743; 25242525; 25609649; 25945542; 26237449; 26267535; 26318036; 27029275; 27546621; 27748879; 31339657; 31422034; 31444342; 32134157; 32225170; 32289284; 32495877; 33101846; 33162808; 33179082; 33483464; |
| Motif | |
| Gene Encoded By | |
| Mass | 36,163 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |