Detail Information for IndEnz0002019305
IED ID IndEnz0002019305
Enzyme Type ID protease019305
Protein Name COP9 signalosome complex subunit 6
SGN6
Signalosome subunit 6
JAB1-containing signalosome subunit 6
MOV34 homolog
Vpr-interacting protein
hVIP
Gene Name COPS6 CSN6 HVIP
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF
Enzyme Length 327
Uniprot Accession Number Q7L5N1
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:9535219}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (9); Chain (1); Domain (1); Erroneous initiation (1); Helix (5); Region (1); Turn (1)
Keywords 3D-structure;Cytoplasm;Direct protein sequencing;Host-virus interaction;Nucleus;Reference proteome;Signalosome
Interact With Q13515; Q9BX70; Q9Y297; Q6UXH8-3; Q8NHY2; Q9UNS2; Q9BT78; Q92905; P28482; P31947; Q92529; Q8N6Y0; Q15911-2
Induction
Subcellular Location SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9535219}. Cytoplasm {ECO:0000269|PubMed:9535219}.; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:9520381}. Note=(Microbial infection) The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. {ECO:0000269|PubMed:9520381}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D Electron microscopy (4); X-ray crystallography (5)
Cross Reference PDB 4D10; 4D18; 4QFT; 4R14; 4WSN; 6R6H; 6R7F; 6R7H; 6R7I;
Mapped Pubmed ID 10391953; 12944386; 14667819; 14742321; 15383276; 15757663; 15811629; 15882621; 16169070; 16223728; 16401342; 16916636; 16943200; 17183367; 17337451; 17353931; 17882165; 18060501; 18093314; 18926707; 19109893; 19214193; 19367725; 19549727; 19609301; 19615732; 19748355; 20360068; 20467437; 20711500; 20855601; 21102408; 21135142; 21317535; 21388382; 21555518; 21900206; 21903422; 21988832; 22118460; 22190034; 22959436; 23095642; 23187808; 23414517; 23453757; 23535662; 23535663; 23583660; 24421388; 25043011; 25144743; 25242525; 25609649; 25945542; 26237449; 26267535; 26318036; 27029275; 27546621; 27748879; 31339657; 31422034; 31444342; 32134157; 32225170; 32289284; 32495877; 33101846; 33162808; 33179082; 33483464;
Motif
Gene Encoded By
Mass 36,163
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda