| IED ID | IndEnz0002019317 |
| Enzyme Type ID | protease019317 |
| Protein Name |
Protein DNA-DAMAGE INDUCIBLE 1 EC 3.4.23.- |
| Gene Name | DDI1 At3g13235 MDC11.6 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MRITVMTAGEQIITLDVDSQETVENVKALLEVESNVPIQQQQLLYNGNEMGNSDKLSALGVKDDDLLMMMVSNASSGSATSAAGNDLGMNPDGSALNPAAFQQHIRGDSNLMGQLFQNDPELAQVISGSDLNKLQDVLRARHRQRSVLQRQKEEELALLYADPFDVEAQRKIEAAIRQKGIDENWEAALEHNPEGFARVIMLYVDMEVNGVPLKAFVDSGAQSTIISKSCAERCGLLRLMDQRYKGIAHGVGQTEILGRIHVAPIKIGNNFYPCSFVVLDSPNMEFLFGLDMLRKHQCTIDLKENVMTVGGGEVSVPFLQEKDIPSRFLDEERVPNDASSSGATVPSGFTEKKNNTVANPTSQQPKRQNTSEGPEFEAKIAKLVELGFSRDSVIQALKLFEGNEEQAAGFLFGG |
| Enzyme Length | 414 |
| Uniprot Accession Number | Q1EBV4 |
| Absorption | |
| Active Site | ACT_SITE 218; /evidence=ECO:0000255|PROSITE-ProRule:PRU00275 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Receptor of ubiquitinated protein targeted to ubiquitin/proteasome-mediated proteolysis (UPP). Relatively weak affinity for both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains with a slight preference for 'Lys-48-'linked chains of three or more ubiquitin units. {ECO:0000269|PubMed:21764993}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Domain (3); Erroneous gene model prediction (1); Mutagenesis (1); Region (1); Sequence conflict (2) |
| Keywords | Aspartyl protease;Cytoplasm;Hydrolase;Protease;Reference proteome;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5TDH0}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16502469; 17227549; 18650403; 22631228; 28627464; |
| Motif | |
| Gene Encoded By | |
| Mass | 45,359 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |