Detail Information for IndEnz0002019317
IED ID IndEnz0002019317
Enzyme Type ID protease019317
Protein Name Protein DNA-DAMAGE INDUCIBLE 1
EC 3.4.23.-
Gene Name DDI1 At3g13235 MDC11.6
Organism Arabidopsis thaliana (Mouse-ear cress)
Taxonomic Lineage cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress)
Enzyme Sequence MRITVMTAGEQIITLDVDSQETVENVKALLEVESNVPIQQQQLLYNGNEMGNSDKLSALGVKDDDLLMMMVSNASSGSATSAAGNDLGMNPDGSALNPAAFQQHIRGDSNLMGQLFQNDPELAQVISGSDLNKLQDVLRARHRQRSVLQRQKEEELALLYADPFDVEAQRKIEAAIRQKGIDENWEAALEHNPEGFARVIMLYVDMEVNGVPLKAFVDSGAQSTIISKSCAERCGLLRLMDQRYKGIAHGVGQTEILGRIHVAPIKIGNNFYPCSFVVLDSPNMEFLFGLDMLRKHQCTIDLKENVMTVGGGEVSVPFLQEKDIPSRFLDEERVPNDASSSGATVPSGFTEKKNNTVANPTSQQPKRQNTSEGPEFEAKIAKLVELGFSRDSVIQALKLFEGNEEQAAGFLFGG
Enzyme Length 414
Uniprot Accession Number Q1EBV4
Absorption
Active Site ACT_SITE 218; /evidence=ECO:0000255|PROSITE-ProRule:PRU00275
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.23.-
Enzyme Function FUNCTION: Receptor of ubiquitinated protein targeted to ubiquitin/proteasome-mediated proteolysis (UPP). Relatively weak affinity for both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains with a slight preference for 'Lys-48-'linked chains of three or more ubiquitin units. {ECO:0000269|PubMed:21764993}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Compositional bias (1); Domain (3); Erroneous gene model prediction (1); Mutagenesis (1); Region (1); Sequence conflict (2)
Keywords Aspartyl protease;Cytoplasm;Hydrolase;Protease;Reference proteome;Ubl conjugation pathway
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5TDH0}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 16502469; 17227549; 18650403; 22631228; 28627464;
Motif
Gene Encoded By
Mass 45,359
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda