| IED ID | IndEnz0002019325 |
| Enzyme Type ID | protease019325 |
| Protein Name |
Probable dipeptidyl peptidase 4 EC 3.4.14.5 Dipeptidyl peptidase IV DPP IV DppIV |
| Gene Name | dpp4 ACLA_048680 |
| Organism | Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Aspergillus clavatus Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) |
| Enzyme Sequence | MKLGKWSVLLLVGCTAAIDIPRKPFPPTGSGHKRLTFNETVVKPVIAPSSTAVEWISTAEDGDYVFQDSDGSLKIQSIVTNHTQTLVPADKVPDDAYSYWIHPNLSSVLWATNYTKQYRYSYFASYYIQDLQSFKLAPLASNQAGDIQYANWSPTGDAIAFVRANNVYVWTAKSTTQITTDGSADLFNGVPDWIYEEEILGDRHALWFSPDAEYLAFLRFNETGVPTFRVPYYMDNEEVAPPYPRELELRYPKVSQTNPTVEVRLLSRATGEVSSVSIKAFNATDLVIGEVAWLTETHSQVAVKAFNRVQDQQKVVTVDVLSLKTKTISERDGTDGWLDNALSITYIGQIGDSKAEYYIDISDESGWAHLWLFPVAGGRPMALTKGEWEVTAILSIDKQRQLVYYLSTQHHSTERHVYSVSWKTFTATPLVDDTVAAVWSASFSSQGGYYILSYRGPDVPYQELYAINSTKPLCTITSNAAVYDVLKQYTLPKISYFELRLPSGETLNVMQRLPVSFSPRKKYPILFTPYGGPGAQEVSKAWQSQTFKSYIASDPELEFVTWTVDNRGTGYKGRRFRGQVAKQLGRLEAQDQVWAAQQAAKLPFIDAEHIAIWGWSYGGYLTGKVIETDSGVFSLGVLTAPVSDWRFYDSMYTERYMKTLQENANGYNASAIWDVAGYKNVRGGVLIQHGTGDDNVHFQNAAALVDRLVGEGVSPDKLQVQWFTDSDHGIRYHGGSVFLYRQLAKRLYEEKHRKKSEGHQWSKRSLEF |
| Enzyme Length | 768 |
| Uniprot Accession Number | A1CHP1 |
| Absorption | |
| Active Site | ACT_SITE 616; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 693; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 728; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; |
| DNA Binding | |
| EC Number | 3.4.14.5 |
| Enzyme Function | FUNCTION: Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Glycosylation (8); Signal peptide (1) |
| Keywords | Aminopeptidase;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 86,453 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |