Detail Information for IndEnz0002019331
IED ID IndEnz0002019331
Enzyme Type ID protease019331
Protein Name Aspartyl aminopeptidase
EC 3.4.11.21
Gene Name dnpep DDB_G0286149
Organism Dictyostelium discoideum (Slime mold)
Taxonomic Lineage cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold)
Enzyme Sequence MEQYLPQAKEFISFIDKSPSPYHAVQYFSEILKSKGFIHLSEKQMWDIQPNKKYFFTRNQSCISAFAVGGKYKPGNGFNIAAAHTDSPNFKVRPVSKVESVGYQQVGVETYGGGLWYTWFDRDLTVAGRVIVKSGDGSYESKLVHIKKPILRIPSLAIHLDRSVNTDGFKYNTQNHLVPMIASKLSEPVESKSTTTTTTTESPKTSDPQDVNSSTTKHHAVLLELLSKELGCSVGDIQNFDLSVCDTQPAAIGGALDEFIFSPRCDNLGMSYCAMIGLLNVKESTLAQEENVLNVILFDNEEVGSSSPQGACAPLINDTISRVNSSMFASTCKPHELNNFIDLTLRNSFLISADMAHAIHPNYTANHEPLHRPALNKGPVIKYNANLRYASNGPTSFVILDICKKNGIPIQEFLVKNDSPCGSTIGPIISGTYGIRTVDIGNPQLSMHSIRETCGVADITHGINLIQKYFEQFTKLDIIKSDLE
Enzyme Length 484
Uniprot Accession Number Q54M70
Absorption
Active Site
Activity Regulation
Binding Site BINDING 159; /note=Substrate; /evidence=ECO:0000250; BINDING 301; /note=Substrate; /evidence=ECO:0000250; BINDING 354; /note=Substrate; /evidence=ECO:0000250; BINDING 357; /note=Substrate; /evidence=ECO:0000250; BINDING 382; /note=Substrate; /evidence=ECO:0000250; BINDING 389; /note=Substrate; /evidence=ECO:0000250
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.; EC=3.4.11.21;
DNA Binding
EC Number 3.4.11.21
Enzyme Function FUNCTION: Likely to play an important role in intracellular protein and peptide metabolism. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Binding site (6); Chain (1); Metal binding (6); Modified residue (1); Region (1)
Keywords Acetylation;Aminopeptidase;Cytoplasm;Direct protein sequencing;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Modified Residue MOD_RES 1; /note=N-acetylmethionine; /evidence=ECO:0000269|Ref.2
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 22120990;
Motif
Gene Encoded By
Mass 53,354
Kinetics
Metal Binding METAL 84; /note=Zinc 1; /evidence=ECO:0000250; METAL 266; /note=Zinc 1; /evidence=ECO:0000250; METAL 266; /note=Zinc 2; /evidence=ECO:0000250; METAL 302; /note=Zinc 2; /evidence=ECO:0000250; METAL 354; /note=Zinc 1; /evidence=ECO:0000250; METAL 448; /note=Zinc 2; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda