| IED ID |
IndEnz0002019334 |
| Enzyme Type ID |
protease019334 |
| Protein Name |
Fibulin-1
|
| Gene Name |
fbl-1 fbln1 F56H11.1 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MRICFLLLAFLVAETFANELTRCCAGGTRHFKNSNTCSSIKSEGTSMTCQRAASICCLRSLLDNACDSGTDIAKEEESCPSNINILGGGLKKECCDCCLLAKDLLNRNEPCVAPVGFSAGCLRSFNKCCNGDIEITHASEIITGRPLNDPHVLHLGDRCASSHCEHLCHDRGGEKVECSCRSGFDLAPDGMACVDRNECLTRQSPCTQSEDCVNTIGGYICQRRISRLVPHRHRANRIGNAPRRMRDDPYSRAGEYREASQANTEFGCPMGWLFQHGHCVDVDECNLGSHDCGPLYQCRNTQGSYRCDAKKCGDGELQNPMTGECTSITCPNGYYPKNGMCNDIDECVTGHNCGAGEECVNTPGSFRCQQKGNLCAHGYEVNGATGFCEDVNECQQGVCGSMECINLPGTYKCKCGPGYEFNDAKKRCEDVDECIKFAGHVCDLSAECINTIGSFECKCKPGFQLASDGRRCEDVNECTTGIAACEQKCVNIPGSYQCICDRGFALGPDGTKCEDIDECSIWAGSGNDLCMGGCINTKGSYLCQCPPGYKIQPDGRTCVDVDECAMGECAGSDKVCVNTLGSFKCHSIDCPTNYIHDSLNKNQIADGYSCIKVCSTEDTECLGNHTREVLYQFRAVPSLKTIISPIEVSRIVTHMGVPFSVDYNLDYVGQRHFRIVQERNIGIVQLVKPISGPTVETIKVNIHTKSRTGVILAFNEAIIEISVSKYPF |
| Enzyme Length |
728 |
| Uniprot Accession Number |
O77469 |
| Absorption |
|
| Active Site |
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| Activity Regulation |
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| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
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| Enzyme Function |
FUNCTION: Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes. {ECO:0000269|PubMed:15556862, ECO:0000269|PubMed:15556863, ECO:0000269|PubMed:16120639, ECO:0000269|PubMed:17043142, ECO:0000269|PubMed:19104038, ECO:0000269|PubMed:22298704}.; FUNCTION: [Isoform a]: Involved in regulating the shape and adhesion of cells in the developing pharynx, intestine, body-wall muscle and gonadal tissue (PubMed:16120639). During gonadogenesis, regulates the width of gonads and the migration of distal tip cells (DTC) (PubMed:15556862, PubMed:17043142, PubMed:22298704). Together with type IV collagen let-2 and downstream of metalloprotease mig-17, recruits nidogen nid-1 to the gonad basement membrane thereby inducing basement membrane remodeling required for the directional migration of DTCs (PubMed:15556863, PubMed:19104038). Acts antagonistically with metalloprotease gon-1 to maintain optimal levels of type IV collagen emb-9 in the gonad basement membrane during gonadogenesis (PubMed:15556862, PubMed:17043142, PubMed:22298704). Required for larval development (PubMed:17043142). {ECO:0000269|PubMed:15556862, ECO:0000269|PubMed:15556863, ECO:0000269|PubMed:16120639, ECO:0000269|PubMed:17043142, ECO:0000269|PubMed:19104038}.; FUNCTION: [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall-muscle basement membranes. {ECO:0000269|PubMed:16120639}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
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| nucleotide Binding |
|
| Features |
Alternative sequence (2); Chain (1); Disulfide bond (30); Domain (12); Glycosylation (1); Mutagenesis (2); Sequence conflict (1); Signal peptide (1) |
| Keywords |
Alternative splicing;Basement membrane;Calcium;Developmental protein;Disulfide bond;EGF-like domain;Extracellular matrix;Glycoprotein;Reference proteome;Repeat;Secreted;Signal |
| Interact With |
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| Induction |
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| Subcellular Location |
SUBCELLULAR LOCATION: [Isoform a]: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:15556862, ECO:0000269|PubMed:15556863, ECO:0000269|PubMed:17043142}. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10615043;
12679813;
14704431;
15338614;
17164286;
17486083;
17850180;
18692475;
19343510;
21110867;
21177967;
21367940;
22051349;
22347378;
22560298;
22981695;
23549480;
23800452;
24318535;
25487147;
26539892;
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| Motif |
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| Gene Encoded By |
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| Mass |
79,321 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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