Detail Information for IndEnz0002019339
IED ID IndEnz0002019339
Enzyme Type ID protease019339
Protein Name Apical membrane antigen 1-like protein
SporoAMA1

Cleaved into: Apical membrane antigen 1-like protein, soluble form
Gene Name TGVEG_315730
Organism Toxoplasma gondii (strain ATCC 50861 / VEG)
Taxonomic Lineage cellular organisms Eukaryota Sar Alveolata Apicomplexa Conoidasida Coccidia Eucoccidiorida Eimeriorina Sarcocystidae Toxoplasma Toxoplasma gondii Toxoplasma gondii type III Toxoplasma gondii (strain ATCC 50861 / VEG)
Enzyme Sequence MPTESRSILARAEETRCRHLSRLLRAGLVFLLCDVLTSCLATPELQNTVIRSSKAHHLQLLFSSRSTPAVKFPLDATLSAPNSFGEQEARSVEAVKQNPWATTTAFADFMKRFNIPQVHGSGIFVDLGRDTEGYREVGGKCPVFGKAIQMHQPAEYSNNFLDDAPTSNDASKKPLPGGFNNPQVYTSGQKFSPIDDSLLQERLGTAGPKTAIGRCALYAYSTIAVNPSTNYTSTYKYPFVYDAVSRKCYVLSVSAQLLKGEKYCSVNGTPSGLTWACFEPVKEKSSARALVYGSAFVAEGNPDAWQSACPNDAVKDALFGKWEDGQCVPFDTKTSVQSDQATNKEECWKRVFANPLVASDAPTTYPEAAQKNWNDFWPVHEQSSPKSGGFGANWANFYLEKESGETICAIFDQVPDCFAPITGAVAYTALGSSTEVNLPQCDSASFIPIEGPCNNCVQVVTECVGNQFDQTSKACCTEPEIIPPVKPPVEPPVEPPVEPPVEPPVEPPVEPPVEPPVEPPVEPPVVEPPTEPSVPEPEPPVVLPPTPGEGGGGGTSGDETVEKEGSGGNTALIAGSVLGMLIILALVGTCVGFYYRKRPLPPTERPTVEASGGREVEGPSDVAVPPDHSWWGEGEHETESLLGSRAVDAEF
Enzyme Length 651
Uniprot Accession Number B6K9M7
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May play a role in host cell invasion. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (23); Chain (2); Compositional bias (1); Disulfide bond (7); Glycosylation (1); Helix (9); Propeptide (1); Region (3); Repeat (12); Signal peptide (1); Site (1); Topological domain (2); Transmembrane (1); Turn (6)
Keywords 3D-structure;Cell membrane;Disulfide bond;Glycoprotein;Membrane;Reference proteome;Repeat;Secreted;Signal;Transmembrane;Transmembrane helix
Interact With
Induction INDUCTION: Readily detected in oocysts (at protein level). Specifically up-regulated in sporozoites, but not in tachyzoites and bradyzoites. {ECO:0000269|PubMed:22279555, ECO:0000269|PubMed:22347997}.
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}. Secreted {ECO:0000250}. Note=Initially localizes to micronemes, specialized secretory organelles of apicomplexan parasites important for host cell invasion. Relocalizes to the surface membrane upon host invasion. {ECO:0000250}.
Modified Residue
Post Translational Modification PTM: Proteolytically cleaved within its transmembrane domain, releasing a soluble form from the cell surface. {ECO:0000250}.
Signal Peptide SIGNAL 1..41; /evidence=ECO:0000255
Structure 3D X-ray crystallography (2)
Cross Reference PDB 3ZLD; 3ZLE;
Mapped Pubmed ID 23940612;
Motif
Gene Encoded By
Mass 69,944
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda