| IED ID | IndEnz0002019351 |
| Enzyme Type ID | protease019351 |
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 8 ADAM 8 EC 3.4.24.- Cell surface antigen MS2 CD antigen CD156a |
| Gene Name | ADAM8 MS2 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP |
| Enzyme Length | 824 |
| Uniprot Accession Number | P78325 |
| Absorption | |
| Active Site | ACT_SITE 335; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Possible involvement in extravasation of leukocytes. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Alternative sequence (6); Beta strand (5); Chain (1); Compositional bias (1); Disulfide bond (12); Domain (3); Glycosylation (4); Helix (8); Metal binding (3); Natural variant (6); Region (2); Sequence conflict (5); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (1) |
| Keywords | 3D-structure;Alternative splicing;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zinc |
| Interact With | Q5T0N5; P14598; P42680; Q15642 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 4DD8; |
| Mapped Pubmed ID | 15623614; 16385451; 17339047; 17548643; 17979891; 18566576; 18682798; 18691140; 18710625; 18811590; 19284887; 19397475; 19469654; 19575316; 19714641; 19766586; 20453887; 20628624; 21077325; 21640993; 21679521; 21728902; 21983884; 22215309; 22229154; 22878099; 22941466; 22959284; 22965687; 23650620; 23670189; 24247244; 24375628; 24526468; 25010013; 25098630; 25336660; 25481287; 25629724; 25825051; 26024798; 27039296; 28596294; 28986926; 29429960; 29750543; 30861616; 31305294; 31347325; 32954649; 33314720; 33544472; 33846772; |
| Motif | |
| Gene Encoded By | |
| Mass | 88,771 |
| Kinetics | |
| Metal Binding | METAL 334; /note=Zinc; catalytic; /evidence=ECO:0000269|PubMed:22684055; METAL 338; /note=Zinc; catalytic; /evidence=ECO:0000269|PubMed:22684055; METAL 344; /note=Zinc; catalytic; /evidence=ECO:0000269|PubMed:22684055 |
| Rhea ID | |
| Cross Reference Brenda |