Detail Information for IndEnz0002019365
IED ID IndEnz0002019365
Enzyme Type ID protease019365
Protein Name Calpain-7
EC 3.4.22.-
PalB homolog
PalBH
Gene Name CAPN7 PALBH
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MDATALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEYLERVQALHSAVQSKSADPLKSKHQLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVGKISSTSVKPKPPPVRAHFPLGANPFLERPQSFISPQSCDAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERFAYPMPFCDRWGKLPLSPKQKTTFSKWVRPEDLTNNPTMIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVIYLSWNPGLFKESTCIHSTWDAKQGPVKDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYYPADPPPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFHIEKTGPLLIELRGPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELENIPSGIFNIIPSTFLPKQEGPFFLDFNSIIPIKITQLQ
Enzyme Length 813
Uniprot Accession Number Q9Y6W3
Absorption
Active Site ACT_SITE 290; /evidence=ECO:0000255|PROSITE-ProRule:PRU00239; ACT_SITE 458; /evidence=ECO:0000255|PROSITE-ProRule:PRU00239; ACT_SITE 478; /evidence=ECO:0000255|PROSITE-ProRule:PRU00239
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.22.-
Enzyme Function FUNCTION: Calcium-regulated non-lysosomal thiol-protease. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Beta strand (9); Chain (1); Domain (1); Helix (2); Modified residue (2); Region (2); Turn (1)
Keywords 3D-structure;Acetylation;Hydrolase;Nucleus;Phosphoprotein;Protease;Reference proteome;Repeat;Thiol protease
Interact With A0A087WVE9; Q9Y2T1; Q96MT8-3; P56545-3; Q08379; Q13099; P53990; Q9Y6D9; Q9Y5V3; Q96KQ4; Q14558; Q13829; P14373; Q8N720
Induction
Subcellular Location SUBCELLULAR LOCATION: Nucleus.
Modified Residue MOD_RES 1; /note=N-acetylmethionine; /evidence=ECO:0007744|PubMed:22814378; MOD_RES 95; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:19690332
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (1)
Cross Reference PDB 2QFE;
Mapped Pubmed ID 12843408; 17608959; 17986458; 20711500; 20849418; 21030783; 21616915; 21670566; 21864727; 23035980; 23497113; 23855590; 24953135; 26496610;
Motif
Gene Encoded By
Mass 92,652
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.4.22.B27;