Detail Information for IndEnz0002019372
IED ID IndEnz0002019372
Enzyme Type ID protease019372
Protein Name Scavenger receptor cysteine-rich type 1 protein M130
CD antigen CD163

Cleaved into: Soluble CD163
sCD163
Gene Name CD163 M130
Organism Canis lupus familiaris (Dog) (Canis familiaris)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Carnivora Caniformia Canidae (dog coyote wolf fox) Canis Canis lupus (Gray wolf) Canis lupus familiaris (Dog) (Canis familiaris)
Enzyme Sequence MSKLRMVPHGNSGSADFRRCFALLCPSAVAVVSILSTCLMTNSLGRADKEMRLTDGEDNCSGRVEVKVQEEWGTVCNNGWGMDEVSVICRQLGCPTAIKAAGWANSRAGSGRIWMDHVSCRGNESALWDCKHDGWGKHNCSHQQDAGVTCSDGSSLEMRLMNGGNQCSGRIEVKFQGQWGTVCDDNFNIDHASVVCKQLECGSAVSFSGSANFGEGSGPIWFDDLVCSGNESALWNCKHEGWGKHNCDHAEDVGVICLDGADLSLRLVDGVTECSGRLEVKFQGEWGTVCDDGWDSNDAAVVCKQLGCPTAVTAIGRVNASEGSGHIWLDNLSCQGDESALWQCRHHEWGKHYCNHNEDAGVTCSDGSDLELRLVGGGSRCAGTVEVEIQKLLGKVCDRGWGLKEADVVCKQLGCGSALKTSYQRYSKVKATNTWLFLSRCSGNETSLWDCKNWQWGGLSCDHYEEAKVTCSAHREPRLVGGDIPCSGRVEVKHGDTWGTVCDSDFSLEAASVLCRELQCGTVISILGGAHFGEGNGQIWAEEFQCEGQESHLSLCSVASRPDGTCSHSRDVGVVCSRYTEIRLVNGQSPCEGRVELKILGNWGSLCNSHWDIEDAHVFCQQLKCGVALSIPGGAHFGKGSGQIWRHMFHCTGTEQHMGDCPVTALGATLCSAGQVASVICSGNQSQTLSPCNSTSLDPTRSTTSEESAVACIASGQLRLVNGGGRCAGRIEVYHEGSWGTICDDSWDLSDAHVVCRQLGCGVAINATGSAHFGEGTGPIWLDEVNCNGKESHIWQCRSHGWGQHNCRHKEDAGVICSEFMSLRLIDETSRDICAGRLEVFYNGAWGSVGKSNMSATTVEVVCRQLGCADKGSINPASSDKPMSRHMWVDNVQCPKGPDTLWQCPSSPWKQRVASSSEETWITCANKIRLQEGTSNCSGRVELWHGGSWGTVCDDSWDLEDAQVVCRQLGCGPALEALKEAAFGQGTGPIWLNDVKCKGNESSLWDCPARPWGHSDCGHKEDAAVRCSEIAMAQRSSNPRGHSSLVALGIFGVILLAFLIALLLWTQRRRQQQRLTVSLRGENSVHQIQYREMNSSLKADDLDVLTSSEYPNESDDFNDAGLISVSKSLPISG
Enzyme Length 1133
Uniprot Accession Number Q2VLG6
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). {ECO:0000250}.; FUNCTION: After shedding, the soluble form (sCD163) may play an anti-inflammatory role. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (1); Chain (2); Disulfide bond (26); Domain (9); Glycosylation (3); Motif (1); Signal peptide (1); Topological domain (2); Transmembrane (1)
Keywords Acute phase;Alternative splicing;Cell membrane;Disulfide bond;Glycoprotein;Inflammatory response;Membrane;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: [Soluble CD163]: Secreted {ECO:0000250|UniProtKB:Q86VB7}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86VB7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q86VB7}.
Modified Residue
Post Translational Modification PTM: A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs (By similarity). {ECO:0000250}.; PTM: Phosphorylated. {ECO:0000250}.
Signal Peptide SIGNAL 1..47; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif MOTIF 1090..1093; /note=Internalization signal
Gene Encoded By
Mass 122,460
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda