IED ID | IndEnz0002019380 |
Enzyme Type ID | protease019380 |
Protein Name |
Transport/processing ATP-binding protein ComA EC 3.4.22.- EC 7.4.2.- |
Gene Name | comA SP_0042 |
Organism | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus pneumoniae Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
Enzyme Sequence | MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPILVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYIFQQILSYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHLLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYINYLSQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLILDEATSSLDILTEKRIVDNLIALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS |
Enzyme Length | 717 |
Uniprot Accession Number | Q03727 |
Absorption | |
Active Site | ACT_SITE 17; /evidence=ECO:0000255|PROSITE-ProRule:PRU00362 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.22.-; 7.4.2.- |
Enzyme Function | FUNCTION: Required for induction of competence. Seems to transport the competence-stimulating peptide (CSP). |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | NP_BIND 517..524; /note="ATP"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00362, ECO:0000255|PROSITE-ProRule:PRU00434" |
Features | Active site (1); Chain (1); Domain (3); Nucleotide binding (1); Sequence conflict (3); Transmembrane (6) |
Keywords | ATP-binding;Cell membrane;Competence;Hydrolase;Membrane;Nucleotide-binding;Protease;Thiol protease;Translocase;Transmembrane;Transmembrane helix;Transport |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 80,404 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |