Detail Information for IndEnz0002019383
IED ID IndEnz0002019383
Enzyme Type ID protease019383
Protein Name Probable dipeptidyl-aminopeptidase B
DPAP B
EC 3.4.14.5
Gene Name DAPB CPC735_039860
Organism Coccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Onygenales incertae sedis Coccidioides Coccidioides posadasii (Valley fever fungus) Coccidioides posadasii (strain C735) (Valley fever fungus)
Enzyme Sequence MGVEKRINDEEMQPLAERDDKSRDSIDSTSTASISLALLGGANGSAHGSRAARTRKSENQEKYHDDEEEGDLEEGFVPPAGGWSAPRKVSVIFTLIVTLCIAGWLVAFFVLLGRHKDSSKDAAVSQGESNIIPGIYSGGRGGKKLDLDGVLFGNWSPKSHDISWFPGPNGADGLLLEQGGDRNKAYLRVEDIRSRNPGNKADDTIVLMRESSFMVGKRLVRPSKVWPSPDLKTVLVMSDQRKNWRHSYTGNYWIFDVETQTGEPLDPESLDGGIQLASWSPNSDAIVFTRKNNMFIRRLPSKNVKQITTDGGTNLFYGIPDWVYEEEVFSDSSATWWDGDGKFVAFLRTNESRVPEYPVQYFIPNTNKPSRPSEENYPDIRKIKYPKAGAPNPVVNIQFFDVEKEEVFSVDVKDDLPDDDRLVIGVTWASNGNVLVRETNRESDRLSVVLIDAAKRAGKVVRSRNFSSLDGGWVEPSQTTHFVPADPKNGRPHDGYIETIPHDGFEHLAYFTPMDNSEPTVLTSGDWEVVDAPSAVDLKRGLVYFVAAKENPTERHIYTVKLDGSDLQPIVDTKSAGYYSISLSAGAGYALLKYEGPDIPWQKVISTPANEEKYEESIEKNPGLADMARKYALPSLHYQTITISGYELQVVERRPANFNPDKKYPVLFHLYGGPGSQTVTKKFKVDFQSYVASNLGYIVVTVDGRGTGFIGRKARCAVRGNLGHYEAIDQIETAKAWGKRSYVDAGRMAIWGWSYGGFMTLKTLEQDAGQTFQYGMAVAPVTDWRFYDSIYTERYMHTPQNNPEGYDRSAISNVTALDQAVRFMIVHGSGDDNVHIQNTLTLLDKLDLGSVKNFDVHVYPDSDHSIYFHNANKMVYQRLSDWLVNAFNGEWVKTRDPIPHKSLARRALGLINILRNG
Enzyme Length 917
Uniprot Accession Number C5P334
Absorption
Active Site ACT_SITE 754; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 831; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 864; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5;
DNA Binding
EC Number 3.4.14.5
Enzyme Function FUNCTION: Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Compositional bias (1); Glycosylation (3); Region (1); Topological domain (2); Transmembrane (1)
Keywords Aminopeptidase;Glycoprotein;Hydrolase;Membrane;Protease;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix;Vacuole
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Lysosome-like vacuoles. {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 102,500
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda