| IED ID | IndEnz0002019396 |
| Enzyme Type ID | protease019396 |
| Protein Name |
Endoplasmic reticulum metallopeptidase 1 EC 3.4.-.- Felix-ina |
| Gene Name | Ermp1 Fxna |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MEWSSESAAVRRHRGTAERREGQAAASHPQREASAQEDARGGGRMRGRTESGGESRGAKTALSEARTALALALYLLALRALVQLSLQRLVLSRTSGLQGEFDARQARVYLEHITAIGPRTTGSAENEILTVQYLLEQITLIEEQSNSLHRISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPQDGAKYAVLANCHFDSVANSPGASDDAVSCAVMLEVLRVMAASPEPLQHAVVFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRILIDSIQRAGDNILAVLKYLATSDMLASSSEYRHGSMVFFDVLGLLVIAYPSRVGSIINYMVVMAVVLYLGRKLLRPNHSNSNYVRDFLCGLGITFISWFTSLVTVLIIAVFVSLIGQSLSWYNYFYIAVCLYGTATVAKIILIHTLAKRFYYVNASDLYLGELFFDTSLFVHCGFLVALTAQGFCSAFMSAVWVAFPLLTKLCVYKDFKKHGAKGRFIALYLLGMFIPYLYGLYLIWAVFEMFTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLVCSGAFFPYSSNPDSPKPKRVFLQHVSRTFHNLEGSVVKRDSGIWINGFDYTGMSHVTPHIPEINDTIRAHCEENAPLCGFPWYLPVHFLIRKNWYLPAPEISPRNPAHFRLVSKEKMPWDSIKLTFEATGPSHMSFYVRTHKGSTLSQWSLGNGIPVTSRGGDYFVFYSHGLQASAWQFWIEVQVSEEQPEGMVTVAIAAHYLSGENKRSSQLDALKEKFPDWSFPSAWVSTYSLFVF |
| Enzyme Length | 898 |
| Uniprot Accession Number | Q6UPR8 |
| Absorption | |
| Active Site | ACT_SITE 245; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. {ECO:0000269|PubMed:17267443}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (2); Disulfide bond (1); Glycosylation (2); Metal binding (6); Modified residue (1); Region (1); Site (1); Topological domain (10); Transmembrane (9) |
| Keywords | Acetylation;Disulfide bond;Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17267443, ECO:0000269|PubMed:23679341}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | MOD_RES 1; /note=N-acetylmethionine; /evidence=ECO:0000250|UniProtKB:Q7Z2K6 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 99,897 |
| Kinetics | |
| Metal Binding | METAL 199; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 211; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 211; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 246; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 272; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 348; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |