Detail Information for IndEnz0004000032
IED ID IndEnz0004000032
Enzyme Type ID xylanase000032
Protein Name Sucrose non-fermenting protein kinase 1
EC 2.7.11.1
Gene Name SNF1 g3696
Organism Fusarium virguliforme
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Hypocreomycetidae Hypocreales Nectriaceae Fusarium Fusarium solani species complex Fusarium virguliforme
Enzyme Sequence MAPRGFEDEELTISLSSSHVRRPQQQQPPPPTQQQHAHQPGSRPADAPLKERIKTEQRIGAYKVLRTLGEGSFGKVKLAIHNGTGQQVALKIIARKKLISRDMAGRVEREIEYLQLLRHPHIIKLYTVIKTPNEIIMVLEYAGGELFDYIVQHGRMKEAEARRFFQQMLCAVEYCHRHKIVHRDLKPENLLLDENLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIGGKLYAGPEVDVWSCGVILYVLLVGRLPFDDEHIPSLFAKIAKGTYSIPQWMPLGAANLIKKMLVVNPVHRATIEDIRADPWFTTELPVYLQLPVEEFFNTGVDPNKAIQKNDIAPNAPEKVQERLHNEVTEKISKTMGYGKNDVEEALQASEPSAIKDAYMIVRENKMMQVNQHPEALLEPEGSSPMLSMSSARSATSTTTTTAPRPYVSKVGILPSSLPAYHKDYVEREKAGSVNNSPPQVLINDELPVTRTDAEKEETSRRLRPHSRSQLRLDEANTRPQGMTPINPPKKTKPVRWQFGIRSRNSPWEALLCIHKALHKLGATYIPDEDYESRHAEERAEASGNGSFADSYDGSRGSTTSIDPMKRYRLPADPWHINVRWDTSAIKKKLQGSADTPDKRQAHEPFVALHLDIQIYEMEHGVYLVDFKCSGYETATGRLLEEKEVTSPFPFLDMAAKLIMQLAEAD
Enzyme Length 698
Uniprot Accession Number P0DP15
Absorption
Active Site ACT_SITE 184; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Activity Regulation
Binding Site BINDING 91; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P06782}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P06782};
DNA Binding
EC Number 2.7.11.1
Enzyme Function FUNCTION: Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes (By similarity). The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters (By similarity). Activates the expression of the galactose oxidase (GOA) gene and of several cell wall-degrading enzymes (CWDEs) such as pectate lyase, xylanase and glucanase (PubMed:28132080). Plays an important role in sudden death syndrome (SDS) by controlling the colonization of the infected roots (PubMed:28132080). {ECO:0000250|UniProtKB:P06782, ECO:0000269|PubMed:28132080}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding NP_BIND 68..76; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Features Active site (1); Binding site (1); Chain (1); Compositional bias (3); Domain (2); Nucleotide binding (1); Region (5)
Keywords ATP-binding;Carbohydrate metabolism;Cytoplasm;Kinase;Nucleotide-binding;Nucleus;Serine/threonine-protein kinase;Transferase;Virulence
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P06782}. Nucleus {ECO:0000250|UniProtKB:P06782}. Note=Nuclear translocation occurs under nitrogen and glucose starvation conditions (By similarity). {ECO:0000250|UniProtKB:P06782}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 78,591
Kinetics
Metal Binding
Rhea ID RHEA:17989; RHEA:46608
Cross Reference Brenda