IED ID |
IndEnz0004000055 |
Enzyme Type ID |
xylanase000055 |
Protein Name |
Sporulation inhibitor of replication protein SirA
|
Gene Name |
sirA yneE yoxF BSU17900 |
Organism |
Bacillus subtilis (strain 168) |
Taxonomic Lineage |
cellular organisms
Bacteria
Terrabacteria group
Firmicutes
Bacilli
Bacillales
Bacillaceae
Bacillus
Bacillus subtilis group
Bacillus subtilis
Bacillus subtilis subsp. subtilis
Bacillus subtilis (strain 168)
|
Enzyme Sequence |
MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEMTEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIEIVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV |
Enzyme Length |
148 |
Uniprot Accession Number |
P45707 |
Absorption |
|
Active Site |
|
Activity Regulation |
|
Binding Site |
|
Calcium Binding |
|
catalytic Activity |
|
DNA Binding |
|
EC Number |
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Enzyme Function |
FUNCTION: Inhibits DNA replication in growing cells, thus reducing chromosome copy number and playing a significant role during the onset of sporulation. {ECO:0000269|PubMed:19329632}. |
Temperature Dependency |
|
PH Dependency |
|
Pathway |
|
nucleotide Binding |
|
Features |
Beta strand (7); Chain (1); Helix (6); Turn (2) |
Keywords |
3D-structure;DNA replication inhibitor;Reference proteome;Sporulation |
Interact With |
|
Induction |
INDUCTION: Up-regulated by spo0A. {ECO:0000269|PubMed:19329632}. |
Subcellular Location |
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Modified Residue |
|
Post Translational Modification |
|
Signal Peptide |
|
Structure 3D |
X-ray crystallography (1) |
Cross Reference PDB |
4TPS;
|
Mapped Pubmed ID |
21239581;
25041308;
|
Motif |
|
Gene Encoded By |
|
Mass |
18,142 |
Kinetics |
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Metal Binding |
|
Rhea ID |
|
Cross Reference Brenda |
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