| IED ID |
IndEnz0004000055 |
| Enzyme Type ID |
xylanase000055 |
| Protein Name |
Sporulation inhibitor of replication protein SirA
|
| Gene Name |
sirA yneE yoxF BSU17900 |
| Organism |
Bacillus subtilis (strain 168) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Terrabacteria group
Firmicutes
Bacilli
Bacillales
Bacillaceae
Bacillus
Bacillus subtilis group
Bacillus subtilis
Bacillus subtilis subsp. subtilis
Bacillus subtilis (strain 168)
|
| Enzyme Sequence |
MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEMTEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIEIVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV |
| Enzyme Length |
148 |
| Uniprot Accession Number |
P45707 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Inhibits DNA replication in growing cells, thus reducing chromosome copy number and playing a significant role during the onset of sporulation. {ECO:0000269|PubMed:19329632}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (7); Chain (1); Helix (6); Turn (2) |
| Keywords |
3D-structure;DNA replication inhibitor;Reference proteome;Sporulation |
| Interact With |
|
| Induction |
INDUCTION: Up-regulated by spo0A. {ECO:0000269|PubMed:19329632}. |
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (1) |
| Cross Reference PDB |
4TPS;
|
| Mapped Pubmed ID |
21239581;
25041308;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
18,142 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|