| IED ID | IndEnz0004000061 |
| Enzyme Type ID | xylanase000061 |
| Protein Name |
DNA topoisomerase 4 subunit B EC 5.6.2.2 Topoisomerase IV subunit B |
| Gene Name | parE grlB BSU18090 |
| Organism | Bacillus subtilis (strain 168) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus subtilis group Bacillus subtilis Bacillus subtilis subsp. subtilis Bacillus subtilis (strain 168) |
| Enzyme Sequence | MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVYEIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKIGKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVFYYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRTKDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQFEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAREEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGAHIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKKVGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEPRRKWIEKNVAFGLDEESNILENENLSVAEEV |
| Enzyme Length | 655 |
| Uniprot Accession Number | Q59192 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | BINDING 9; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_00939; BINDING 49; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_00939; BINDING 76; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_00939; BINDING 340; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_00939 |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000255|HAMAP-Rule:MF_00939}; |
| DNA Binding | |
| EC Number | 5.6.2.2 |
| Enzyme Function | FUNCTION: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. {ECO:0000255|HAMAP-Rule:MF_00939}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 116..122; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_00939 |
| Features | Binding site (4); Chain (1); Compositional bias (1); Domain (1); Erroneous initiation (1); Metal binding (4); Nucleotide binding (1); Region (1); Site (4) |
| Keywords | ATP-binding;DNA-binding;Isomerase;Magnesium;Metal-binding;Nucleotide-binding;Reference proteome;Topoisomerase |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 73,007 |
| Kinetics | |
| Metal Binding | METAL 429; /note=Magnesium 1; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_00939; METAL 502; /note=Magnesium 1; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_00939; METAL 502; /note=Magnesium 2; /evidence=ECO:0000255|HAMAP-Rule:MF_00939; METAL 504; /note=Magnesium 2; /evidence=ECO:0000255|HAMAP-Rule:MF_00939 |
| Rhea ID | |
| Cross Reference Brenda |