| IED ID | IndEnz0004000083 |
| Enzyme Type ID | xylanase000083 |
| Protein Name |
Two pore calcium channel protein 1 OsTPC1 Voltage-dependent calcium channel protein TPC1 |
| Gene Name | TPC1 Os01g0678500 LOC_Os01g48680 B1144G04.26-1 OsJ_03004 |
| Organism | Oryza sativa subsp. japonica (Rice) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae BOP clade Oryzoideae Oryzeae Oryzinae Oryza Oryza sativa (Rice) Oryza sativa subsp. japonica (Rice) |
| Enzyme Sequence | MRERGEMREAKAPLIAEAAEHISHSHGSGSSGTGSHTSGGGGGWRGSRQYQRRSDALAYGNRYQKAAALVDLAEDGVGIPEDVLNDTRFERAMRFYFVYLRLDWLWSLNLFALILLNFLEKPLWCRGYSQHACDQRDLYFLGQLPYLSKTESLIYEGLTLVILVMDIFYPLSYEGLNLFWKNTINKLKVLLLFILACDILVFAFSPQPFRVAPYIRVAFLIMNIRELRMCAVTLVGMVGTYLNVLALSLLFLLFASWLAYVTFEDTPQGKTVFSSYGTTLYQMFILFTTSNNPDVWVPAYKSSRWSSLFFIVYVLLGVYFLTNLILAVIYDSFKEQLAKQVSQADCTRKSILEKAFGIIDATGQGYLNKEQCLSLLDELNKYRSLPKTSREDFELIFAELDQSGDFKVTSEEFATLCNTIAIKFQKEPPPSYLEKYPSFYHSALCEWLKSFVRSPLFEYIVIFVLLMNLVAVIIETTLDIENSSSQKVWQEVEFVFGWIYVIEMALKIFSLGFGAYWMEGQNKFDFVLTWTIFIGETLTFAFPSKLSFLSNGEWIRYLLLGRMLRLTRILLQVRRFRAFVATFFTLMSSLMPYLGIVFCTLCIYCSLGLQIFGGIVYAGNPTLEETDLFSNDYLLFNFNDYPSGMVTLFNLLVMGNWQAWMESYRQLTGSYWSLIYFVSFYLISVLLLLNLIVAFVLEAFFAEMELEKDGEADIQDPTLEGRNRRRSVRVRTKGTMVDILLHHMLSNELDGSQNRDQ |
| Enzyme Length | 757 |
| Uniprot Accession Number | Q5QM84 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by the VDCC blocker verapamil in yeast cells. Channel activity may be down-regulated by cytosolic Ca(2+) in rice cells. Inhibited by Al(3+) (By similarity). {ECO:0000250}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May function as one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane. May be involved in the regulation of cytosolic Ca(2+) and in growth and development. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Determines sensitivity to T.viride xylanase elicitor. Plays a regulatory role in elicitor-induced defense responses and hypersensitive cell death. {ECO:0000269|PubMed:15111725, ECO:0000269|PubMed:15215504, ECO:0000269|PubMed:15941394}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Domain (2); Erroneous gene model prediction (1); Glycosylation (1); Intramembrane (2); Region (1); Sequence conflict (1); Topological domain (15); Transmembrane (12) |
| Keywords | Calcium;Calcium channel;Calcium transport;Glycoprotein;Ion channel;Ion transport;Membrane;Plant defense;Reference proteome;Repeat;Transmembrane;Transmembrane helix;Transport;Voltage-gated channel |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15111725, ECO:0000269|PubMed:15215504, ECO:0000269|PubMed:15941394}; Multi-pass membrane protein {ECO:0000269|PubMed:15111725, ECO:0000269|PubMed:15215504, ECO:0000269|PubMed:15941394}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15913561; 19395386; 22270358; 22990444; 23845012; |
| Motif | |
| Gene Encoded By | |
| Mass | 87,069 |
| Kinetics | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=47.5 uM for Ca(2+) (at 30 degrees Celsius) {ECO:0000269|PubMed:15111725}; Note=Measured in yeast knockout mutant cch1.; |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |