| IED ID | IndEnz0005000034 |
| Enzyme Type ID | lipase000034 |
| Protein Name |
GPI inositol-deacylase EC 3.1.-.- Post-GPI attachment to proteins factor 1 |
| Gene Name | PGAP1 CG3160 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MFMFRNCAVLLVIGSICCFIYGLFRLHVEVEPNACRMTYMFGEPMFAKVGVRDGDQYPNYALYYYYEGLRQPLDPLKRRMTGAPVIFVPGNAGSYKQVRSLASVALRKAMSNDAGIHLDYYTIDYDEELSALYGGYLHRQQSYLKLCIRTILSIYEGRTEQPSIVLIGHSMGGKLAQSVLVDPAIGQHINTIISISTPLDQPVLNLDTQLEEFYDQTDAVLSKLRTATVPTMTTNVCDSLHQRPPSVQRMASQDSSARLDNVLLISTGGGNRDLLVRPGLTSSRFNDLHAMTSAIPKVSLSCDHLSAVWCLQFMQAINRFLFSVAYVREDRSSIAFGTNKQRNLQTALSTFVKPRRRQQNTVRFGAAGNWHEERRLVINKYFTNGLKGTFFDLIGLQRQERYRKAAIEALNVDDEDWLFGCSAEDNNKTGQLYCEKATSLMHLVQWLPNEDREPRSIALLDLHNLRKTYVHWTHLLVRLPPSAKRIGYNLDIYDPKERVTDIKMPRWYTMAKLPLINETLQGTLHHRVRISEMVDPYQSIRVIVEPLQCINPEYRVTARICVPWAAGFERFQTLKSFDQKPQLYVNVPTLVPRHYNTTLNPVTLELYLDPTCRYRISYEYSYSSALSRLVLEFYGWLPAHLVCVLLIVLRKQVETFYDVGTFRSLRPYVGYLQYTSLYIVTACRLLKKLIISSRVFPEPEPLDYSINVSIVIHCAAIALSLLATLGTWLALTLYGNAFYRLALRITRLSQATSNVMISIMTHLPITYGILTIATAMGTCSGVGLLLAFVFYFLMLSNAYKDYLEDFLWQKAANLVRGKPSAVTEQEDATEEQNEEQNALKQNDEQKQQQQEEEEPEACVGLQNFSFHVTLLLMLFVQLLLNAPSSLAWLRSRRHGINLPDPSLYPSIVVLASLSLLLQLRAPQKCQGYWMLSIAFYILAGVVLLYCQAAIYRLTYVIAGAFALLSAHQSLWILWGRVSRV |
| Enzyme Length | 980 |
| Uniprot Accession Number | Q9W495 |
| Absorption | |
| Active Site | ACT_SITE 170; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.1.-.- |
| Enzyme Function | FUNCTION: Involved in inositol deacylation of GPI-anchored proteins. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Glycosylation (3); Region (1); Sequence conflict (2); Topological domain (9); Transmembrane (8) |
| Keywords | Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Protein transport;Reference proteome;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12618398; 14605208; 15711536; 15936330; 16452134; 20220848; 20371351; 21074052; 22574122; 23071443; 23238734; 23250212; 25158796; 25294943; 25312911; 25681415; 25687947; 26551273; 27172210; 33827210; |
| Motif | |
| Gene Encoded By | |
| Mass | 111,625 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |