| IED ID | IndEnz0005000038 |
| Enzyme Type ID | lipase000038 |
| Protein Name |
GPI inositol-deacylase EC 3.1.-.- Post-GPI attachment to proteins factor 1 |
| Gene Name | pgap1 |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MNPLSAVFNSVVLVLLALGVTDVFFSYESSRCSMTYMFEYPQYLQIKLSKKVSRLYPLYELYLYGEGSYAEENKNLTLTGVPVLFLPGNAGSYKQARSFASVALRKAENIGNRYHFNIFTVNFNEELVALYGGSLRRQTRFVHECIKTILSLYKNQTFPPESVAIIGHSMGGLVARALFTLKHFKPDLINVIITQATPHILPVLSTDIYLTDFYTMVNNYWIYNSLKLRNITMLSVAGGYSDYQVRSGLTFLPTSSFHTSALSVVSSAVPITWASTDHLSIVWCRELVLVTARALFDLIDEHTKQINIDPQSRMSVIKHHFVRHPAKHLESRHQITASFTETPKFTLVEDSKWTYTVNKESNESFFLFPLLDKRIAYSHFHCQNTFLYTHSWIFGCNKTVSPKCLQINDLSWETELLPSAKVVNLKLDVYSNLSHFILYIPATNGSKFSVECEFLSEEARTVHVPVTHVLSFGFSSSHAPLNSSGLLYVIQFEDFSKIYQAFNVFIVRNCGQNKESKSSIYKFHVPWSHEDLIGVLSDELPVRISAKLHAEQPQNDNRLVKLFLYASPECLHEVTISTSFSQILGQIVRFHGIYLPVYIVANLLLAYGAQLHSILIQGSCMDLDLSFDVAAKPYKVDPVLIICKYLLNYKWFKNYWDGLMLPQLDAVQLHAYGFWFPLASLFFFIFGTSIAYWSSIGLQAAVRILSSLWIYLKRPSMFPKESKCITYRVYAETLFFAFISWRSCGTFSLLLVFLRYLSKVLILYSSMKNYVSLNAHIVKDTSSKQDSVKTDSDTNINSNQLTHHQPSSLEIKALDDCLKMHFTILHLNLWIVLLGLPSFIYWLKTLRYTIQLDPDPNRVSALVLIFILEILMNSTTSAIKSSVCLKTAAVLQLPLSIIVVAFGTLHLYRISNLIAFSLFLHVVCCFV |
| Enzyme Length | 927 |
| Uniprot Accession Number | Q66J01 |
| Absorption | |
| Active Site | ACT_SITE 169; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.1.-.- |
| Enzyme Function | FUNCTION: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (8); Topological domain (8); Transmembrane (7) |
| Keywords | Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Protein transport;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 105,636 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |