| IED ID | IndEnz0005000121 |
| Enzyme Type ID | lipase000121 |
| Protein Name |
Linearmycin resistance ATP-binding protein LnrL EC 7.6.2.- |
| Gene Name | lnrL bifL yfiL BSU08310 |
| Organism | Bacillus subtilis (strain 168) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus subtilis group Bacillus subtilis Bacillus subtilis subsp. subtilis Bacillus subtilis (strain 168) |
| Enzyme Sequence | MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTISMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMYGLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPTVGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTDLCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSLLAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD |
| Enzyme Length | 311 |
| Uniprot Accession Number | P94440 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 7.6.2.- |
| Enzyme Function | FUNCTION: Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes (PubMed:26647299, PubMed:28461449). Part of the ABC transporter complex LnrLMN that probably facilitates linearmycin removal from the membrane. Responsible for energy coupling to the transport system (PubMed:28461449). Also mediates KinC-dependent biofilm morphology (PubMed:28461449). {ECO:0000269|PubMed:26647299, ECO:0000269|PubMed:28461449}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 34..41; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00434 |
| Features | Chain (1); Domain (1); Nucleotide binding (1); Sequence conflict (1) |
| Keywords | ATP-binding;Nucleotide-binding;Reference proteome;Translocase;Transport |
| Interact With | |
| Induction | INDUCTION: Induced in response to linearmycins and other polyenes via the two-component regulatory system LnrJ/LnrK. {ECO:0000269|PubMed:28461449}. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 34,050 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |