| IED ID | IndEnz0005000231 |
| Enzyme Type ID | lipase000231 |
| Protein Name |
Serotonin-gated chloride channel mod-1 Modulation Of locomotion defective protein 1 |
| Gene Name | mod-1 K06C4.6 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MKFIPEITLLLLLFVHSTQAKGKRRKCPEGAWSEGKIMNTIMSNYTKMLPDAEDSVQVNIEIHVQDMGSLNEISSDFEIDILFTQLWHDSALSFAHLPACKRNITMETRLLPKIWSPNTCMINSKRTTVHASPSENVMVILYENGTVWINHRLSVKSPCNLDLRQFPFDTQTCILIFESYSHNSEEVELHWMEEAVTLMKPIQLPDFDMVHYSTKKETLLYPNGYWDQLQVTFTFKRRYGFYIIQAYVPTYLTIIVSWVSFCMEPKALPARTTVGISSLLALTFQFGNILKNLPRVSYVKAMDVWMLGCISFVFGTMVELAFVCYISRCQNSVRNAERRRERMRNSQVWANGSCRTRSNGYANGGSVISHYHPTSNGNGNNNRHDTPQVTGRGSLHRNGPPSPLNLQMTTFDSEIPLTFDQLPVSMESDRPLIEEMRSTSPPPPSGCLARFHPEAVDKFSIVAFPLAFTMFNLVYWWHYLSQTFDQNYQ |
| Enzyme Length | 489 |
| Uniprot Accession Number | Q9GQ00 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Functions as a 5-hydroxytryptamine (serotonin) receptor (PubMed:11100728, PubMed:12783521, PubMed:23023001). This receptor is a ligand-gated anion-specific ion channel, selective for chloride ions (PubMed:11100728, PubMed:15878844). Relays a long-range endocrine signal from the body cavity neurons to modulate distal adipose triglyceride lipase atgl-1 function, via the nuclear receptor nhr-76 (PubMed:24120942). Together with the G-protein coupled serotonin receptor ser-1 involved in male mating behavior (PubMed:16291940). May mediate an inhibitory effect of serotonin on egg laying (PubMed:16291940). Involved in regulating locomotory behavior, perhaps by modulating interneuronal signaling, acting in concert with G-protein coupled serotonin receptor ser-4 (PubMed:19193891, PubMed:23023001). In the presence of food, plays a role in initiating and extending dwelling behavior, perhaps acting in AIY, RIF and ASI neurons, in opposition to neuropeptide PDF-mediated signaling (PubMed:23972393). Plays a role in aversive learning upon exposure to pathogens such as Gram-negative bacterium P.aeruginosa strain PA14; perhaps acting in interneurons in response to serotonin released by the serotonergic ADF neurons (PubMed:16281027). {ECO:0000269|PubMed:11100728, ECO:0000269|PubMed:12783521, ECO:0000269|PubMed:15878844, ECO:0000269|PubMed:16281027, ECO:0000269|PubMed:16291940, ECO:0000269|PubMed:19193891, ECO:0000269|PubMed:23023001, ECO:0000269|PubMed:23972393, ECO:0000269|PubMed:24120942}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (3); Chain (1); Glycosylation (3); Mutagenesis (4); Region (2); Signal peptide (1); Topological domain (2); Transmembrane (4) |
| Keywords | Alternative splicing;Cell membrane;Coiled coil;Glycoprotein;Ion channel;Ion transport;Membrane;Plasmid;Reference proteome;Signal;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:12783521}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 15177025; 18033297; 18522834; 18984564; 19536276; 19675228; 19851507; 20739712; 21529784; 22267497; 22286215; 22491324; 22560298; 22901814; 23800452; 23852451; 24465759; 24884423; 24910101; 25487147; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 56,143 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |