| IED ID |
IndEnz0005000267 |
| Enzyme Type ID |
lipase000267 |
| Protein Name |
Colipase
|
| Gene Name |
clps |
| Organism |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amphibia
Batrachia
Anura
Pipoidea
Pipidae
Xenopodinae
Xenopus
Silurana
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
|
| Enzyme Sequence |
MNIFNILLPIVVLLLVFGLTAAIPDEKGLIFNLDNGELCLQTAQCKSGCCHRNSGVSLARCAPKAAETQKCSPLHIYGTYYFCPCESGLTCEVDRSIVGSITNTDYGYCEDQNNTTI |
| Enzyme Length |
117 |
| Uniprot Accession Number |
A9JSD6 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. {ECO:0000255|PROSITE-ProRule:PRU00674}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (5); Signal peptide (1) |
| Keywords |
Digestion;Disulfide bond;Lipid degradation;Lipid metabolism;Reference proteome;Secreted;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000255|PROSITE-ProRule:PRU00674}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
12,717 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|