| IED ID | IndEnz0005000277 |
| Enzyme Type ID | lipase000277 |
| Protein Name |
Thermolabile hemolysin TL Atypical phospholipase Lecithin-dependent hemolysin LDH Lysophospholipase Phospholipase A2 |
| Gene Name | VPA0226 |
| Organism | Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Vibrionales Vibrionaceae Vibrio Vibrio harveyi group Vibrio parahaemolyticus Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) |
| Enzyme Sequence | MMKKTITLLTALLPLASAVAEEPTLSPEMVSASEVISTQENQTYTYVRCWYRTSYSKDDPATDWEWAKNEDGSYFTIDGYWWSSVSFKNMFYTNTSQNVIRQRCEATLDLANENADITFFAADNRFSYNHTIWSNDAAMQPDQINKVVALGDSLSDTGNIFNASQWRFPNPNSWFLGHFSNGFVWTEYIAKAKNLPLYNWAVGGAAGENQYIALTGVGEQVSSYLTYAKLAKNYKPANTLFTLEFGLNDFMNYNRGVPEVKADYAEALIRLTDAGAKNFMLMTLPDATKAPQFKYSTQEEIDKIRAKVLEMNEFIKAQAMYYKAQGYNITLFDTHALFETLTSAPEEHGFVNASDPCLDINRSSSVDYMYTHALRSECAASGAEKFVFWDVTHPTTATHRYVAEKMLESSNNLAEYRF |
| Enzyme Length | 418 |
| Uniprot Accession Number | Q99289 |
| Absorption | |
| Active Site | ACT_SITE 153; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 390; /evidence=ECO:0000250; ACT_SITE 393; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Phospholipase hydrolyzing both fatty acid esters of phospholipid, i.e. it hydrolyzes phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) and then LPC to glycerophosphorylcholine (GPC). |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Natural variant (1); Sequence conflict (3); Signal peptide (1) |
| Keywords | Cytolysis;Direct protein sequencing;Hemolysis;Hydrolase;Lipid degradation;Lipid metabolism;Reference proteome;Secreted;Signal;Toxin;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: There are two forms of LDH. The LDH(S) may be a protein in which 13 residues of the N-terminal of LDH(L) are deleted. |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000269|PubMed:1791426 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 47,392 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |