| IED ID |
IndEnz0005000305 |
| Enzyme Type ID |
lipase000305 |
| Protein Name |
Colipase
|
| Gene Name |
Clps |
| Organism |
Mus musculus (Mouse) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Glires (Rodents and rabbits)
Rodentia
Myomorpha (mice and others)
Muroidea
Muridae
Murinae
Mus
Mus
Mus musculus (Mouse)
|
| Enzyme Sequence |
MEKVLVLLLVSLLAVAYAAPGPRGLIINLEDGEICLNSMQCKSRCCQHDTILGIARCTHKAMENSECSPKTLYGIYYRCPCERGLTCEGDRSIIGAITNTNYGICLDSRRSKQ |
| Enzyme Length |
113 |
| Uniprot Accession Number |
Q9CQC2 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. {ECO:0000269|PubMed:10769148}.; FUNCTION: Enterostatin has a biological activity as a satiety signal. {ECO:0000305}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (5); Propeptide (1); Signal peptide (1) |
| Keywords |
Digestion;Disulfide bond;Lipid degradation;Lipid metabolism;Reference proteome;Secreted;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..18; /evidence=ECO:0000250 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
11217851;
11751900;
12388789;
12466851;
14610273;
15760467;
15905332;
16946080;
18554416;
19622781;
2045105;
21267068;
21339507;
21677750;
23012479;
23676500;
24194600;
8105016;
8288233;
8672143;
8798769;
8827514;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
12,445 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|