| IED ID |
IndEnz0005000309 |
| Enzyme Type ID |
lipase000309 |
| Protein Name |
Fibroblast growth factor 21
FGF-21
|
| Gene Name |
FGF21 UNQ3115/PRO10196 |
| Organism |
Homo sapiens (Human) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
| Enzyme Sequence |
MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPALPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS |
| Enzyme Length |
209 |
| Uniprot Accession Number |
Q9NSA1 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity. {ECO:0000250|UniProtKB:Q9JJN1, ECO:0000269|PubMed:15902306, ECO:0000269|PubMed:17623664}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (1); Chain (1); Compositional bias (2); Natural variant (2); Region (1); Sequence conflict (1); Signal peptide (1); Turn (1) |
| Keywords |
3D-structure;Direct protein sequencing;Growth factor;Reference proteome;Secreted;Signal |
| Interact With |
P46379-2; P55212; O14645; Q0VDC6; P54652; Q86Z14; O14901; P13473-2; O43765; Q96EQ0 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9JJN1}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..28; /evidence=ECO:0000269|PubMed:15340161 |
| Structure 3D |
X-ray crystallography (1); NMR spectroscopy (2) |
| Cross Reference PDB |
5VAQ;
6M6E;
6M6F;
|
| Mapped Pubmed ID |
11425315;
11681785;
17068132;
17452648;
17926232;
18252893;
18559909;
18680716;
18722685;
18840768;
19059246;
19318452;
19401423;
19487637;
19528204;
19531592;
19681655;
19699495;
19702724;
19720803;
19926712;
20332535;
20362303;
20451522;
20452080;
20566587;
20629328;
20675007;
20682689;
20717167;
21123446;
21206918;
21309058;
21373720;
21502324;
21505329;
21521346;
21521350;
21525989;
21596453;
21664250;
21666694;
21691104;
21696361;
21712364;
21750278;
21767451;
21812521;
21820356;
21849508;
21889884;
21949781;
21988350;
21988832;
22013098;
22046277;
22136913;
22152380;
22190000;
22233381;
22248288;
22262056;
22293928;
22344195;
22378787;
22398021;
22438225;
22442730;
22523080;
22529197;
22539584;
22701542;
22740503;
22881230;
23123503;
23129782;
23278761;
23283977;
23372041;
23533568;
23545215;
23626003;
23667629;
23736373;
23759753;
23768789;
23782039;
23840612;
23887638;
23912560;
23943793;
23981342;
24078096;
24142477;
24184811;
24205333;
24260557;
24369918;
24397811;
24432989;
24612017;
24700140;
24724557;
24733293;
24735204;
24769090;
24813368;
24841294;
24848261;
24895044;
24895642;
24907231;
25013999;
25039824;
25055037;
25137423;
25170079;
25170746;
25194937;
25300595;
25359230;
25365322;
25411238;
25538153;
25549692;
25604041;
25625802;
25659979;
25664662;
25675147;
25722462;
25766411;
25781694;
25814554;
25843656;
25850006;
25868802;
25929297;
25985218;
26047614;
26055067;
26068142;
26091256;
26092866;
26241324;
26274346;
26294388;
26329882;
26338887;
26529252;
26567701;
26797127;
26823820;
26867126;
26872317;
26884286;
26887040;
26915669;
26950284;
26962859;
26982498;
27003131;
27010621;
27061435;
27106505;
27118870;
27164684;
27179139;
27179781;
27226639;
27285327;
27305706;
27318658;
27453549;
27482056;
27505721;
27548521;
27581055;
27583468;
27593966;
27611701;
27650781;
27794108;
27794110;
27832059;
27916484;
28005535;
28039838;
28106545;
28123933;
28123934;
28139438;
28225059;
28326329;
28359360;
28422956;
28467924;
28582462;
28588089;
28588304;
28591702;
28698650;
28735064;
28759185;
28820393;
28821258;
28825598;
28887067;
28965199;
29031905;
29077838;
29107287;
29107295;
29299795;
29342135;
29351855;
29367522;
29410351;
29427162;
29436198;
29462798;
29476704;
29528583;
29581470;
29608670;
29754168;
29768065;
29771383;
29953859;
30019838;
30043445;
30089729;
30185439;
30198244;
30228048;
30298107;
30307155;
30317562;
30334297;
30346647;
30446181;
30578395;
30641825;
30688648;
30888221;
30926667;
31152776;
31178962;
31205953;
31241504;
31255518;
31289229;
31323006;
31372821;
31413360;
31455871;
31523008;
31672443;
31798902;
31817052;
31915301;
31977105;
31997152;
32066255;
32101022;
32188054;
32210348;
32220662;
32267096;
32267352;
32431189;
32469231;
32504279;
32513031;
32546231;
32602078;
32684151;
32756564;
32857451;
32911033;
32929325;
32979381;
33071964;
33097385;
33125701;
33131010;
33132219;
33162410;
33264784;
33295692;
33310036;
33330965;
33383173;
33387664;
33436812;
33571698;
33588820;
33617873;
33670024;
33713667;
33753729;
33770382;
33789910;
33810243;
33849110;
33907846;
33924457;
33946944;
33995273;
34019585;
34167789;
34203775;
34321008;
34360670;
34405516;
34572118;
34591968;
34836209;
34939977;
34972147;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
22,300 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|