| IED ID | IndEnz0005000317 |
| Enzyme Type ID | lipase000317 |
| Protein Name |
Lysophospholipase-like protein 1 EC 3.1.2.22 |
| Gene Name | Lyplal1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MAAVPSAVHLPRCVVSPTGRHSASLIFLHGSGHSGQGQREWIKHVLNQDLTFQHIKIIYPTAPSRPYTPLKGGLSNVWFDRFKISMDCPEHLESIDSMCQVLSGLIDEEVKTGIQKSRILIGGFSMGGCMAMHLAYRSHPDVAGVFVLSGFLNKASVVYQDLQQGGRMLPELFQCHGSADNLVLHAWGKETNSKLKSLGVSTTFHSLPNLNHELNKTELEKLKSWILTRLPGETDGQSE |
| Enzyme Length | 239 |
| Uniprot Accession Number | Q3UFF7 |
| Absorption | |
| Active Site | ACT_SITE 125; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 180; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 212; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence={ECO:0000250|UniProtKB:Q5VWZ2};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19234; Evidence={ECO:0000250|UniProtKB:Q5VWZ2}; |
| DNA Binding | |
| EC Number | 3.1.2.22 |
| Enzyme Function | FUNCTION: Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Initiator methionine (1); Modified residue (1); Sequence conflict (3) |
| Keywords | Acetylation;Cytoplasm;Hydrolase;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | MOD_RES 2; /note=N-acetylalanine; /evidence=ECO:0000250|UniProtKB:Q5VWZ2 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12477932; 21677750; 22399288; 24194600; 25958046; 26275310; 26839965; 27626380; 29084768; 30639359; |
| Motif | |
| Gene Encoded By | |
| Mass | 26,354 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:19233; RHEA:19234 |
| Cross Reference Brenda |