| IED ID | IndEnz0005000319 |
| Enzyme Type ID | lipase000319 |
| Protein Name |
Neuroligin-3 Gliotactin homolog |
| Gene Name | Nlgn3 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MWLQPSLSLSPTPTVGRSLCLTLGFLSLVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGAPELGTAPEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNSLVGLQTLHPYNTFAAGFNSTGLPHSHSTTRV |
| Enzyme Length | 825 |
| Uniprot Accession Number | Q8BYM5 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. {ECO:0000269|PubMed:16982420}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (23); Chain (1); Compositional bias (1); Disulfide bond (3); Glycosylation (2); Helix (25); Modified residue (2); Region (2); Sequence conflict (2); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (6) |
| Keywords | 3D-structure;Cell adhesion;Cell junction;Cell membrane;Disulfide bond;Glycoprotein;Membrane;Phosphoprotein;Reference proteome;Signal;Synapse;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17897391}; Single-pass type I membrane protein {ECO:0000269|PubMed:17897391}. Cell junction, synapse {ECO:0000269|PubMed:17897391}. Note=Detected at both glutamatergic and GABAergic synapses. |
| Modified Residue | MOD_RES 722; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q62889; MOD_RES 769; /note=Phosphotyrosine; /evidence=ECO:0007744|PubMed:18034455 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..34; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 7CEE; 7CEG; |
| Mapped Pubmed ID | 12466851; 14610273; 15681343; 16186258; 16602821; 16615898; 16635246; 17540781; 17823315; 18227507; 18854036; 19139271; 19360662; 19406211; 19607885; 20163789; 20579107; 20630950; 21267068; 21642956; 21677750; 21788371; 21808020; 22633921; 22671294; 22983708; 23010509; 23226954; 23583622; 24046374; 24151012; 24619977; 24995986; 25144834; 25299583; 25347860; 25592157; 25693924; 26291161; 26403076; 26469287; 27050589; 27080031; 27452274; 27581450; 27725662; 28067903; 28255463; 28607166; 28708891; 28795135; 28864826; 28921757; 28939043; 28959975; 29100073; 29503190; 29724786; 29742426; 30056576; 30093665; 30123111; 30201312; 30664619; 30871858; 31379628; 31827744; 32327975; 32381505; 32669345; 32719346; 32760004; 32879325; 32973045; 33335150; 33347690; 33355091; 33758193; 34040258; 34262438; 34715405; |
| Motif | |
| Gene Encoded By | |
| Mass | 91,162 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |