| IED ID | IndEnz0005000345 |
| Enzyme Type ID | lipase000345 |
| Protein Name |
Neuroligin-3 Gliotactin homolog |
| Gene Name | NLGN3 KIAA1480 NL3 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MWLRLGPPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAQGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGAGAPELGAAPEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNSLVGLQTLHPYNTFAAGFNSTGLPHSHSTTRV |
| Enzyme Length | 848 |
| Uniprot Accession Number | Q9NZ94 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). {ECO:0000250, ECO:0000269|PubMed:15620359}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Chain (1); Compositional bias (1); Disulfide bond (3); Erroneous initiation (2); Glycosylation (2); Modified residue (2); Natural variant (5); Region (2); Sequence caution (1); Sequence conflict (2); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Asperger syndrome;Autism;Autism spectrum disorder;Cell adhesion;Cell junction;Cell membrane;Disease variant;Disulfide bond;Glycoprotein;Membrane;Phosphoprotein;Reference proteome;Signal;Synapse;Transmembrane;Transmembrane helix |
| Interact With | P49753; P05108; P68104; Q8IWB1; P00403; Q15274; Q86W33 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Detected at both glutamatergic and GABAergic synapses. {ECO:0000250}. |
| Modified Residue | MOD_RES 745; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q62889; MOD_RES 792; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:Q8BYM5 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..37; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10433268; 10433269; 10806096; 11498055; 11604393; 15274046; 15389766; 15540461; 15622415; 16077734; 16242404; 16508939; 16624946; 16648374; 16846852; 17292328; 17897391; 18189281; 18628683; 18812509; 18829961; 19058789; 19406211; 19645625; 20227402; 21282647; 21569590; 21988832; 22671294; 23431752; 23468870; 23851596; 24570023; 25378172; 25913192; 26496610; 27782075; 27805570; 28948087; 28959975; 29503438; 29792861; 31119867; 31150649; 31184401; 31705895; 7695896; 7736595; 8576240; 9024696; 9115257; 9221768; 9927700; |
| Motif | |
| Gene Encoded By | |
| Mass | 93,895 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |