| IED ID |
IndEnz0005000367 |
| Enzyme Type ID |
lipase000367 |
| Protein Name |
Neuroligin-1
|
| Gene Name |
NLGN1 KIAA1070 |
| Organism |
Homo sapiens (Human) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
| Enzyme Sequence |
MALPRCTWPNYVWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKGGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV |
| Enzyme Length |
863 |
| Uniprot Accession Number |
Q8N2Q7 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development. {ECO:0000250|UniProtKB:Q99K10, ECO:0000269|PubMed:28841651}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Alternative sequence (1); Beta strand (26); Chain (1); Disulfide bond (3); Erroneous initiation (2); Glycosylation (6); Helix (25); Natural variant (7); Region (3); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (7) |
| Keywords |
3D-structure;Alternative splicing;Autism;Autism spectrum disorder;Biological rhythms;Cell adhesion;Cell junction;Cell membrane;Disease variant;Disulfide bond;Glycoprotein;Membrane;Reference proteome;Secreted;Signal;Synapse;Transmembrane;Transmembrane helix |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28841651}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62765}. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:Q62765}. Cell junction, synapse, synaptic cleft {ECO:0000250|UniProtKB:Q62765}. Cell junction, synapse, synaptic cell membrane {ECO:0000250|UniProtKB:Q62765}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. {ECO:0000250|UniProtKB:Q62765}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..45; /evidence=ECO:0000255 |
| Structure 3D |
X-ray crystallography (2) |
| Cross Reference PDB |
5OJ6;
5OJK;
|
| Mapped Pubmed ID |
10433268;
10433269;
10806096;
11498055;
11604393;
11937501;
14522992;
15540461;
15797875;
16077734;
16242404;
16624946;
16846852;
17897391;
18812509;
18829961;
18987618;
19086053;
19598235;
19730411;
19736351;
20201926;
20379614;
20398908;
20516156;
20677014;
21282647;
21838267;
23264101;
23719805;
23853109;
23929743;
24439376;
24502978;
25378172;
25399301;
25428619;
26078884;
26109803;
26440732;
26674772;
28817804;
31665629;
31801062;
33522967;
34340665;
7695896;
7736595;
8576240;
9024696;
9115257;
9221768;
9927700;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
96,368 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|