| IED ID | IndEnz0005000423 |
| Enzyme Type ID | lipase000423 |
| Protein Name |
Carboxylesterase 1C EC 3.1.1.1 Liver carboxylesterase N Lung surfactant convertase PES-N |
| Gene Name | Ces1c Es1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MWLHALVWASLAVCPILGHSLLPPVVDTTQGKVLGKYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMCSQDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIGGASPYNGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLSQCNDTSSAAMVQCLRQKTESELLEISGKLVQYNISLSTMIDGVVLPKAPEEILAEKSFNTVPYIVGFNKQEFGWIIPMMLQNLLPEGKMNEETASLLLRRFHSELNISESMIPAVIEQYLRGVDDPAKKSELILDMFGDIFFGIPAVLLSRSLRDAGVSTYMYEFRYRPSFVSDKRPQTVEGDHGDEIFFVFGAPLLKEGASEEETNLSKMVMKFWANFARNGNPNGEGLPHWPEYDEQEGYLQIGATTQQAQRLKAEEVAFWTELLAKNPPETDPTEHTEHK |
| Enzyme Length | 554 |
| Uniprot Accession Number | P23953 |
| Absorption | |
| Active Site | ACT_SITE 221; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039; ACT_SITE 342; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 455; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10039}; |
| DNA Binding | |
| EC Number | 3.1.1.1 |
| Enzyme Function | FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (2); Frameshift (1); Glycosylation (5); Modified residue (1); Motif (1); Sequence caution (1); Sequence conflict (25); Signal peptide (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Endoplasmic reticulum;Glycoprotein;Hydrolase;Phosphoprotein;Reference proteome;Serine esterase;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Note=Microsomal membrane, lumen of endoplasmic reticulum. |
| Modified Residue | MOD_RES 473; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P10959 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10087289; 1008801; 1016231; 10441734; 1133851; 1180875; 12466851; 1316514; 13972292; 14328418; 1445184; 14681479; 1477475; 1535334; 1632635; 16615898; 1684952; 1686838; 1694015; 170908; 1783403; 1820020; 1883319; 1887331; 19651238; 1968046; 1973375; 1981050; 2037298; 20931200; 2108401; 21267068; 216346; 21659478; 21677750; 21767560; 21875074; 23012479; 23658012; 2383242; 2413215; 2505256; 25285996; 25392229; 2563260; 2565878; 2571572; 2571576; 28659436; 2897121; 2902634; 297012; 2993648; 2999153; 31924756; 32027397; 3209851; 32668216; 3417135; 3447590; 3866909; 3995927; 4084216; 4193185; 4353891; 4451294; 4841975; 4933322; 5251879; 5365621; 5372803; 540008; 5520794; 5588789; 5799428; 5961479; 6276492; 6278049; 6283161; 6375655; 6517849; 6788549; 6838491; 7115286; 7151411; 7558020; 7576184; 75870; 7613040; 7663508; 7774940; 8014601; 8094303; 8228167; 8321202; 8422497; 8615905; 8666240; 869894; 8903730; 9069116; 926748; |
| Motif | MOTIF 551..554; /note=Prevents secretion from ER; /evidence=ECO:0000255 |
| Gene Encoded By | |
| Mass | 61,056 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:21164 |
| Cross Reference Brenda | 3.1.1.1; |