IED Industry Enzyme Database

Detail Information for IndEnz0005000455
IED ID IndEnz0005000455
Enzyme Type ID lipase000455
Protein Name Apolipoprotein A-I
Apo-AI
ApoA-I
Apolipoprotein A1

Cleaved into: Proapolipoprotein A-I
ProapoA-I
; Truncated apolipoprotein A-I
Apolipoprotein A-I
1-242
Gene Name APOA1
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ
Enzyme Length 267
Uniprot Accession Number P02647
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (3); Glycosylation (1); Helix (7); Modified residue (2); Natural variant (33); Region (1); Repeat (10); Sequence conflict (1); Signal peptide (1); Turn (2)
Keywords 3D-structure;Amyloid;Amyloidosis;Atherosclerosis;Cholesterol metabolism;Direct protein sequencing;Disease variant;Glycation;Glycoprotein;HDL;Lipid metabolism;Lipid transport;Lipoprotein;Neuropathy;Oxidation;Palmitate;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal;Steroid metabolism;Sterol metabolism;Transport
Interact With O95477; Itself; P05067; Q07021; Q96DZ9; Q96DZ9-2; P00738; P13473-2; P04180; Q9Y371; P37840
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue MOD_RES 110; /note=Methionine sulfoxide; /evidence=ECO:0000269|PubMed:12576517; MOD_RES 136; /note=Methionine sulfoxide; /evidence=ECO:0000269|PubMed:12576517
Post Translational Modification PTM: Glycosylated. {ECO:0000250}.; PTM: Palmitoylated. {ECO:0000269|PubMed:3005308}.; PTM: Phosphorylation sites are present in the extracellular medium.
Signal Peptide SIGNAL 1..18; /evidence="ECO:0000269|PubMed:6328445, ECO:0000269|PubMed:6409108"
Structure 3D Electron microscopy (2); X-ray crystallography (3); NMR spectroscopy (20)
Cross Reference PDB 1AV1; 1GW3; 1GW4; 1ODP; 1ODQ; 1ODR; 2MSC; 2MSD; 2MSE; 2N5E; 3K2S; 3R2P; 4V6M; 6CC9; 6CCH; 6CCX; 6CLZ; 6CM1; 6PTS; 6PTW; 6W4E; 6W4F; 7KJR; 7RSC; 7RSE;
Mapped Pubmed ID 10103054; 10215547; 10339590; 10371504; 10381560; 10391242; 10411933; 10428310; 10431236; 10583407; 10686426; 10722588; 10734051; 10764676; 10772654; 10840998; 10873640; 10938017; 11055796; 11060341; 11063469; 11095984; 11171287; 11181747; 11181758; 11264435; 11284697; 11297421; 11401442; 11467836; 11472750; 11476961; 11507973; 11561168; 11572515; 11718686; 11737222; 11744719; 11756058; 11773045; 11776109; 11805090; 11836686; 11860752; 11861652; 11866037; 11866932; 118839; 11888526; 11903341; 11907138; 11916081; 11929608; 11931574; 11963567; 11988484; 12000358; 12011770; 12030900; 12044583; 12048121; 12084722; 12105195; 12111381; 12116231; 12123106; 12130498; 12138091; 12145244; 12150950; 12167653; 12173940; 12177172; 12270762; 12369845; 12376530; 12421824; 12458630; 12462973; 12468059; 12473160; 12488451; 12509412; 12509503; 12509922; 12511593; 12515395; 12518019; 12531890; 12544508; 12556235; 12573451; 12588323; 12642784; 12651854; 12690114; 12692252; 12692552; 1270801; 12709430; 12722515; 12724319; 12732844; 12742997; 12754494; 12754559; 12763022; 12788804; 1279089; 12791946; 12798568; 12801612; 12818417; 12871600; 12875674; 12917409; 12928428; 12947091; 12952980; 12962772; 12964943; 12974138; 1339697; 14510906; 14559902; 14563824; 14567398; 14570867; 14580163; 14592415; 14592845; 14609337; 14609958; 14630798; 14660648; 14665416; 14666619; 14701824; 14729861; 14732096; 14734645; 14741338; 14746139; 14967052; 14988232; 15001567; 15020600; 15036610; 15051721; 1505654; 15060083; 15066991; 15115711; 15174051; 15177130; 15188057; 15218078; 15242863; 15258834; 15280376; 15292375; 15297675; 15304365; 15314690; 15334687; 15359539; 15362856; 15464323; 15474503; 15476409; 15498766; 15533931; 15540281; 15574409; 15576377; 15583000; 15584908; 15585206; 15649902; 15654128; 15657615; 15690042; 15694942; 15695525; 15722561; 15723520; 15751988; 15766290; 15782489; 15805548; 15823278; 15849246; 15868628; 1587806; 15882068; 15910632; 15925353; 15952766; 15961173; 15962178; 15962837; 15972827; 15982502; 15994327; 16005361; 16005451; 16005460; 16009332; 1601989; 16023124; 16046400; 16053196; 16060677; 16091367; 16126721; 16130094; 16136540; 16169070; 16197951; 16200213; 16236546; 16259956; 16276419; 16285990; 16309370; 16326978; 16342934; 16368749; 16380821; 16403951; 16417409; 16418537; 16443932; 16455106; 16475830; 16495141; 16497665; 16520487; 16542392; 16545386; 16548525; 16574896; 16671566; 16698792; 16705465; 16710093; 16763159; 16770077; 16778136; 16781717; 16801176; 16895799; 16926412; 16931800; 16939214; 16968945; 17020879; 17071617; 17071967; 17101731; 17113061; 17142127; 17165100; 17204472; 17216278; 17237796; 17261136; 17272829; 17298957; 17303779; 17378725; 17447731; 17457002; 17474718; 17475009; 17478755; 17510466; 17517342; 17526499; 17530370; 17530866; 17563120; 17580958; 17600344; 17604270; 17644776; 17652309; 17654446; 17683612; 17693625; 17696931; 17698072; 17709607; 17727676; 17761633; 17825930; 17845074; 17853951; 17855807; 17868679; 17876058; 17919884; 17938634; 17950741; 17964293; 17967773; 17991432; 18063807; 18073484; 18179892; 18193043; 18193044; 18193046; 18202432; 18206649; 18218626; 18252847; 18257091; 18280807; 18316036; 18322452; 1837051; 18378026; 18385134; 18387362; 18388068; 18398670; 18406360; 18449172; 18458151; 18484335; 1849145; 18506369; 18507396; 18515783; 1852209; 18558917; 18562802; 18565099; 1856611; 18566298; 18583707; 18594986; 18597093; 18621920; 18622028; 18624398; 18660489; 18678879; 18682504; 18688016; 18695102; 18719109; 18719128; 18774540; 18776170; 18801202; 18805838; 18823627; 18824596; 18831538; 18848320; 18927546; 18988890; 18988892; 19013290; 19022789; 19023195; 19035465; 19048603; 19060906; 19060911; 19066833; 19074352; 19105467; 19116237; 19122170; 19124125; 19155782; 19170766; 19171400; 19191080; 19207029; 19208510; 19217440; 19218819; 19227971; 19237602; 19237735; 19239199; 19242900; 19258317; 19285487; 19304335; 19318685; 19324878; 19324996; 19327233; 19336370; 19336475; 19339807; 19408098; 19473658; 19481824; 19528336; 19551315; 19558216; 19578796; 19592705; 19618959; 19635584; 19636829; 19651918; 19667106; 19701693; 19729689; 19732897; 19740687; 19740737; 19758344; 19762782; 19765778; 19766218; 1977072; 19786567; 19802338; 19812036; 19863188; 19878569; 19911804; 19913121; 19917453; 19932694; 19945452; 19948731; 19948975; 19956635; 19965585; 20008415; 20031551; 20059975; 20064972; 20080084; 20083572; 20110571; 20133843; 20143106; 20164363; 20167577; 20182709; 20195290; 20197510; 20213498; 20215705; 20331378; 20349521; 20360068; 20360967; 20368199; 20376577; 20378541; 20382384; 20385548; 20394740; 20399916; 20413122; 20421239; 20430392; 20442857; 20452482; 20459474; 20480398; 20524691; 20534134; 20538481; 20539018; 20571754; 20578904; 20599735; 20602615; 20622162; 20634891; 20642861; 20656001; 20660328; 20673868; 20674306; 20683626; 20693280; 20714348; 20727869; 20800056; 20801516; 20805508; 20807650; 20826588; 20835684; 20842444; 20847045; 20849212; 20855565; 20869895; 20884842; 20888598; 20953506; 21033077; 21040803; 21047795; 21069432; 21115733; 21122686; 21122859; 21129746; 21138461; 21141907; 21145806; 21156318; 2118650; 21209084; 21292766; 21296086; 21329368; 21330603; 21339300; 21354994; 21355296; 21367423; 21394531; 21399642; 21399863; 21416664; 21420943; 21443680; 21452855; 21499241; 21504968; 21549099; 21571275; 21576418; 21631938; 21640348; 21676393; 21677994; 21730889; 21734188; 21749932; 21755356; 21761133; 21767760; 21782039; 21800421; 21801720; 21804189; 21811627; 21820994; 21835924; 21840419; 21846716; 21854571; 21868729; 21870882; 21900206; 21911577; 21914797; 21944998; 2195544; 21988832; 22028648; 22056562; 22105741; 22119776; 22211563; 22219194; 22229410; 22235130; 22245143; 22271762; 22282358; 22287661; 22295944; 22297598; 22320308; 22389325; 22407494; 22418575; 22441101; 22471842; 22483015; 2251254; 22609356; 22619369; 22675253; 22750655; 22889670; 22924697; 22952757; 22986928; 23037322; 23066790; 23067370; 23088652; 23096223; 23119086; 23121297; 23125458; 23152129; 23154241; 23183508; 2318890; 23209431; 23219399; 23233540; 23233678; 23300094; 23322769; 23359805; 23385359; 23409054; 23410546; 23420675; 23425306; 23438152; 23447138; 23454085; 23457133; 23479152; 23543682; 23564081; 23568022; 23580759; 23631828; 23650622; 23668303; 23690001; 23697869; 23701995; 23726972; 23730806; 23740387; 23758329; 23806608; 23826352; 23829168; 23883582; 23889245; 23902290; 23936200; 23969698; 23973688; 23984834; 23994331; 24008390; 24015188; 24028463; 24038215; 24038317; 24081495; 24089247; 2409350; 24120703; 24136289; 24148653; 24201377; 24209603; 24285582; 24304668; 24308268; 24308948; 24316228; 24357674; 24376512; 24407029; 24464187; 24508624; 24523407; 24548082; 24558038; 24603325; 24608795; 24661883; 24702826; 24709669; 24710015; 24793484; 24797978; 24820970; 24825900; 24885977; 24919401; 24922540; 24925720; 24926085; 24955142; 24969553; 25023050; 25025299; 25113039; 25115832; 25117102; 25170076; 25194312; 25227208; 25241761; 25248404; 25341944; 25359426; 25374385; 25392541; 25415591; 25416956; 25423138; 25445031; 25451254; 25463085; 25465061; 25468275; 25528002; 25550459; 25561462; 25613532; 25651728; 25653052; 25692941; 25759391; 25789510; 25793886; 25818853; 25820252; 25849372; 25884165; 25890187; 25913481; 25920915; 25941399; 25950566; 25964115; 25969892; 25979856; 26005953; 26048453; 26049118; 26070092; 26086425; 26091039; 26118305; 26168996; 26173491; 26175149; 26200866; 26207725; 26238231; 26261631; 26292220; 26337083; 26359513; 26363436; 26363640; 26368306; 26420021; 26491253; 26496610; 26503474; 26537097; 26543096; 26552698; 26562506; 26582246; 26617857; 26661731; 26662883; 26681753; 26682220; 26687706; 26758372; 26774504; 26813964; 26819136; 26820473; 26868508; 26966279; 26994915; 26996551; 27015844; 27017521; 27094595; 27100352; 27122373; 27155060; 27155339; 27173266; 27183204; 27199144; 27233433; 27240838; 27317763; 27377933; 27404023; 27444612; 27526664; 27599772; 27683106; 27734225; 27758769; 27768903; 27790714; 27816355; 27846285; 2793848; 279930; 28024148; 28038449; 28042708; 28073663; 28093456; 28167355; 28181168; 28238629; 28279834; 28304324; 2833496; 28372564; 28378321; 28391888; 28408323; 28445313; 28502492; 28540474; 28578353; 28595037; 28635360; 28644829; 28710487; 28754383; 28770971; 28802864; 28957410; 28969676; 28992985; 2900981; 29030428; 29031392; 29032752; 29074586; 29074589; 29150341; 29154726; 29174954; 29208698; 29277345; 29287080; 29359590; 29377875; 29378195; 29401604; 29440006; 29442267; 29447225; 29581158; 29618705; 29618920; 29623474; 29626583; 29680706; 29712830; 29747660; 29758034; 29773713; 29776362; 29802959; 29853648; 29859275; 29915952; 29968409; 30004304; 30004693; 30096856; 30119683; 30122370; 30132720; 30184436; 30249788; 30328580; 30343478; 3035556; 30367981; 30458687; 30467071; 30471921; 30488199; 30509867; 30510601; 3053705; 30556889; 30635405; 30659061; 30718702; 3080684; 3081805; 30821416; 30858459; 3094007; 30970222; 30971477; 30996342; 31003938; 31080037; 31188743; 31211449; 31391051; 31401190; 31482740; 31599692; 31678510; 31682461; 31765698; 31779197; 31783518; 31863971; 31904503; 31936876; 31945064; 31980684; 31981042; 32092318; 32113648; 32189309; 32194045; 32227412; 32282500; 32414921; 32437778; 32491935; 32546165; 32563265; 32587976; 32666307; 32758395; 32810603; 32841328; 32919081; 32946930; 32950994; 32961276; 33029257; 33216373; 33413027; 33430253; 33591433; 33652957; 33717107; 33753020; 33794863; 33853556; 33861588; 34055102; 34131170; 34135129; 34181800; 34206021; 34275798; 34311082; 34472376; 34500559; 34666674; 3467373; 34703570; 34723873; 34851955; 3942763; 4335615; 4340992; 4345202; 5057882; 6088540; 6255257; 6619141; 7536797; 7607209; 7670941; 7683668; 7685021; 7688729; 8088506; 8088507; 8096444; 8097946; 8127896; 8159701; 8429030; 8464497; 8490014; 8728311; 8751442; 8784195; 8870004; 9006323; 9026529; 9054935; 9148899; 9211901; 9225214; 9254056; 9354635; 9409200; 9465098; 9511720; 9548586; 9748239; 9829992; 9834113; 9862427; 9925661;
Motif
Gene Encoded By
Mass 30,778
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda