IED ID | IndEnz0005000477 |
Enzyme Type ID | lipase000477 |
Protein Name |
Colipase Fragment |
Gene Name | |
Organism | Squalus acanthias (Spiny dogfish) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Chondrichthyes Elasmobranchii (elasmobranchs) Selachii (sharks) Squalomorphii Squaliformes Squalidae (dogfish sharks) Squalus Squalus acanthias (Spiny dogfish) |
Enzyme Sequence | APERGLFLNLSAGELCVGSFQCKSSCCQRETGLSLARCA |
Enzyme Length | 39 |
Uniprot Accession Number | P11149 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Chain (1); Disulfide bond (2); Non-terminal residue (1) |
Keywords | Digestion;Direct protein sequencing;Disulfide bond;Lipid degradation;Lipid metabolism;Secreted |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 4,107 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |