Detail Information for IndEnz0005000490
IED ID IndEnz0005000490
Enzyme Type ID lipase000490
Protein Name Response regulator GacA
Global activator
Gene Name gacA PA2586
Organism Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas aeruginosa group Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Enzyme Sequence MIKVLVVDDHDLVRTGITRMLADIEGLQVVGQADCGEDCLKLARELKPDVVLMDVKMPGIGGLEATRKLLRSQPDIKVVVVTVCEEDPFPTRLMQAGAAGYMTKGAGLEEMVQAIRQVFAGQRYISPQIAQQLALKSFQPQQHDSPFDSLSEREIQIALMIANCHKVQSISDKLCLSPKTVNTYRYRIFEKLSITSDVELALLAVRHGMVDAAS
Enzyme Length 214
Uniprot Accession Number Q51373
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding DNA_BIND 167..186; /note=H-T-H motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU00411
EC Number
Enzyme Function FUNCTION: Positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); DNA binding (1); Domain (2); Modified residue (1); Sequence conflict (1)
Keywords Activator;Autoinducer synthesis;DNA-binding;Phosphoprotein;Reference proteome;Transcription;Transcription regulation;Two-component regulatory system;Virulence
Interact With
Induction
Subcellular Location
Modified Residue MOD_RES 54; /note=4-aspartylphosphate; /evidence=ECO:0000255|PROSITE-ProRule:PRU00169
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 23,609
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda