| IED ID | IndEnz0005000490 |
| Enzyme Type ID | lipase000490 |
| Protein Name |
Response regulator GacA Global activator |
| Gene Name | gacA PA2586 |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas aeruginosa group Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
| Enzyme Sequence | MIKVLVVDDHDLVRTGITRMLADIEGLQVVGQADCGEDCLKLARELKPDVVLMDVKMPGIGGLEATRKLLRSQPDIKVVVVTVCEEDPFPTRLMQAGAAGYMTKGAGLEEMVQAIRQVFAGQRYISPQIAQQLALKSFQPQQHDSPFDSLSEREIQIALMIANCHKVQSISDKLCLSPKTVNTYRYRIFEKLSITSDVELALLAVRHGMVDAAS |
| Enzyme Length | 214 |
| Uniprot Accession Number | Q51373 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | DNA_BIND 167..186; /note=H-T-H motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU00411 |
| EC Number | |
| Enzyme Function | FUNCTION: Positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); DNA binding (1); Domain (2); Modified residue (1); Sequence conflict (1) |
| Keywords | Activator;Autoinducer synthesis;DNA-binding;Phosphoprotein;Reference proteome;Transcription;Transcription regulation;Two-component regulatory system;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 54; /note=4-aspartylphosphate; /evidence=ECO:0000255|PROSITE-ProRule:PRU00169 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 23,609 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |