| IED ID | IndEnz0005000509 |
| Enzyme Type ID | lipase000509 |
| Protein Name |
Protein mxl-3 Basic-helix-loop-helix transcription factor 3 Max-like protein 3 |
| Gene Name | mxl-3 hlh-23 F46G10.6 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MSAIVEDMYLLSSSMKMEKQFRKRHHSDSSDDDSSSPKSASPSMDDDRRAHHNELERRRRDHIKDHFTILKDAIPLLDGEKSSRALILKRAVEFIHVMQTKLSSQGKAIEDLTRKNELLEERLLERESSGSPSSSRLPALAVSSSQMQLTMPIIPQMQNIAQLSQYPQQANIIAQSTNPAQLDGLIALNNDAILALLGSFQSVSPSLLDSAPGTPPSGFYPCAFSPVDQQMAVKI |
| Enzyme Length | 235 |
| Uniprot Accession Number | Q18711 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Transcription factor which regulates the expression of genes involved in lipid metabolism in response to nutrient availability (PubMed:23604316, PubMed:29113111). Binds to the E-box motif 5'-CACGTG-3' (PubMed:19632181). Under well-fed conditions, binds to the promoter and represses the expression of lipase genes lipl-1, lipl-2, lipl-3 and to a lesser extent lipl-5, thereby preventing lipolysis (PubMed:23604316). In response to a high-glucose diet, promotes fatty acid synthesis, elongation and desaturation by up-regulating transcription factor sbp-1 expression (PubMed:29113111). Under well-fed conditions, acts remotely in the intestine to up-regulate the expression of chemoreceptor srh-234 gene in the ADL sensory neuron, possibly by regulating the insulin signaling pathway (PubMed:27487365). {ECO:0000269|PubMed:19632181, ECO:0000269|PubMed:23604316, ECO:0000269|PubMed:27487365, ECO:0000269|PubMed:29113111}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Domain (1); Region (3) |
| Keywords | Activator;Cytoplasm;DNA-binding;Nucleus;Reference proteome;Repressor;Transcription;Transcription regulation |
| Interact With | |
| Induction | INDUCTION: Down-regulated by fasting. {ECO:0000269|PubMed:23604316}. |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23604316, ECO:0000269|PubMed:29113111}. Cytoplasm {ECO:0000269|PubMed:29113111}. Note=In response to nutrient levels, shuttles between the cytoplasm and the nucleus (PubMed:29113111). Localizes to the nucleus in response to high glucose levels (PubMed:29113111). {ECO:0000269|PubMed:29113111}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17513831; 18794350; 21110867; 21177967; 22037705; 22560298; 23791784; 23800452; 24068555; 25487147; 26430702; |
| Motif | |
| Gene Encoded By | |
| Mass | 26,040 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |