| IED ID | IndEnz0005000515 |
| Enzyme Type ID | lipase000515 |
| Protein Name |
Patatin-like phospholipase domain-containing protein 5 EC 3.1.1.3 |
| Gene Name | Pnpla5 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MDFLEAEGGWNLSFSGSGYMGLYHVGVTQCLRQRAPRLIQGARRFYGSSSGALNAMAIVFGKSADFACSNLLDLVKLVERLSLGIFHPAYGPAEHIRKKLYENLPDNCHILASQRLGISMTRWPDGKNFIVTDFATRDEFIQALICTLYLPLYCGVIPPAFRGQRFIDGALSNNLPFSDCPTTITVSPFNGTVDICPQNISHSLFELTAFNASFQISTRNFFRGLKSVFPPKPEVVADHCRQGYLDALRFLERRGLTKEPVLWSLVSKEPPALVEGPRGTGHDQGQKTGPTVRWDIPNVLVKDVPNFELLSPELEAALRKACKRDFWTRVQCSVPGKVLAYLLLPCTLPFEYAYFRSRRLMEWLPEAPDDLDWMRSILKSTTLEVYSMAKSWLLRLGSPPGTRADSGLLRQQRGTAPSGNRPLNHRWFPGMD |
| Enzyme Length | 432 |
| Uniprot Accession Number | Q32LZ8 |
| Absorption | |
| Active Site | ACT_SITE 49; /note=Nucleophile; /evidence=ECO:0000255|PROSITE-ProRule:PRU01161; ACT_SITE 168; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000250|UniProtKB:Q7Z6Z6};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence={ECO:0000250|UniProtKB:Q7Z6Z6}; |
| DNA Binding | |
| EC Number | 3.1.1.3 |
| Enzyme Function | FUNCTION: Has abundant triacylglycerol lipase activity. {ECO:0000250|UniProtKB:Q7Z6Z6}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (1); Chain (1); Domain (1); Motif (3); Region (1) |
| Keywords | Alternative splicing;Hydrolase;Lipid degradation;Lipid metabolism;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 12466851; |
| Motif | MOTIF 16..21; /note=GXGXXG; /evidence=ECO:0000255|PROSITE-ProRule:PRU01161; MOTIF 47..51; /note=GXSXG; /evidence=ECO:0000255|PROSITE-ProRule:PRU01161; MOTIF 168..170; /note=DGA/G; /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 |
| Gene Encoded By | |
| Mass | 48,480 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:12044; RHEA:12045 |
| Cross Reference Brenda |